Abstract:

BACKGROUND: Pneumocystis carinii pneumonia (PCP) is a kind of lethal pneumonia caused by pneumocystis carinii (PC) which is parasitize lung. Sulfamethoxazole is a first-line drug for PCP treatment, while there is obvious side effect when using therapeutic dose. The efficacy and side effect of small dose of SMZ is unclear.
OBJECTIVE: To observe the effect of small dose of compound sulfamethoxazole (SMZco) for prevention of PCP after kidney transplantation.
METHODS: Patients who were taken kidney transplantation for just one month and not sensitive to SMZco were selected. All the participants took SMZco (0.48 g/d) for half a year to one year. The graft and liver function, infection situation and side effects were surveyed.
RESULTS AND CONCLUSION: We finally enrolled 125 patients in which 73 participants took SMZco for half a year and other 47 for 1 year. As a result, one patient who took SMZvo for half a year was died of PCP at 4 months after drug withdraw. While no one died in the 1 year treatment group. In addition, there were 5 patients had not taken SMZco for hypersusceptibility or bad compliance in which 2 cases caught PCP after 4 and 5 months respectively and 1 cases died. Using small dose of SMZco at 1 month after kidney transplantation for 1 year is effective for prevention of PCP and has no side effect.