Chinese Journal of Tissue Engineering Research ›› 2026, Vol. 30 ›› Issue (17): 4529-4541.doi: 10.12307/2026.139

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Visual analysis of cuproptosis research: global landscape of hotspots and frontiers

Li Ruiying1, Xia Hong2   

  1. 1Forth Clinical School, Capital Medical University, Beijing 100176, China; 2School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
  • Received:2025-04-24 Accepted:2025-08-10 Online:2026-06-18 Published:2025-12-05
  • Contact: Xia Hong, PhD, Associate professor, School of Biomedical Engineering, Capital Medical University, Beijing 100069, China
  • About author:Li Ruiying, Forth Clinical School, Capital Medical University, Beijing 100176, China
  • Supported by:
    the National Research Association of Computer Basic Education in Colleges and Universities of China, No. 2024-AFCEC-105 (to XH); the Scientific Research and Innovation Project of Capital Medical University, No. XSKY2024160 (to XH)

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Abstract: BACKGROUND: Cuproptosis, as an emerging form of cell death, has garnered widespread attention in recent years. However, there is a lack of systematic understanding of the global research dynamics of cuproptosis, especially the research priorities and trends in different countries and academic communities. A multi-database, multi-faceted bibliometric analysis is urgently needed to provide a more comprehensive understanding of the research progress in the field of cuproptosis.
OBJECTIVE: To systematically analyze the research status, hotspots, and development trends in the field of cuproptosis using bibliometric methods.
METHODS: Using bibliometric methods combined with CiteSpace and VOSviewer visualization and analysis tools, we retrieved and analyzed 1 378 cuproptosis-related literature published from 2022 to 2024 in the international authoritative Web of Science core collection database and the China Knowledge Network database (CNKI). This analysis included annual publication volume, research cooperation network, keyword co-occurrence, clustering and hotspot change characteristics, and highly cited literature. By comparing and analyzing the data from these two databases, we aim to reveal the overall landscape of cuproptosis research from a global perspective.
RESULTS AND CONCLUSION: Cuproptosis research has shown a rapid growth trend, with China leading in the number of publications, where institutions such as Shanghai Jiao Tong University and Central South University serve as the core institutions. The research theme focuses on the mechanism of cuproptosis, tumor therapeutic application (chemokinetic therapy) and cross-regulation with ferroptosis. The keyword emergence analysis showed that "immune microenvironment" and "tumor therapy" are the research hotspots. Machine-learning gene prediction models and single-cell sequencing technologies are driving the development of precision medicine. Most of the English studies focus on the exploration of mechanisms and application of technologies. Their research methods, technical routes and hot directions are of great significance to the cuproptosis research in China, which is in the rapid development period. In particular, interdisciplinary cooperation and multi-center clinical translational research in the field of tumor treatment and other major diseases are expected to provide more targeted and effective new strategies for the diagnosis and treatment of malignant tumors and other major diseases, including the Chinese population.
Funding: the National Research Association of Computer Basic Education in Colleges and Universities of China, No. 2024-AFCEC-105 (to XH); the Scientific Research and Innovation Project of Capital Medical University, No. XSKY2024160 (to XH)

Key words: cuproptosis, bibliometrics, visual analysis, CiteSpace, VOSviewer, research progress, tumor therapy, immune infiltration

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