Medium- and long-term efficacy and safety of domestic and imported rapamycin-eluting stents

doi:10.3969/j.issn.2095-4344.2013.03.028

Abstract

Abstract:

BACKGROUND: The use of drug-eluting stents in the treatment of coronary atherosclerotic heart disease is effective in decreasing restenosis after percutaneous transluminal coronary artery angioplasty and major adverse cardiac events in medium- and long-term.
OBJECTIVE: To assess the safety and efficacy of domestic and imported rapamycin-eluting stents for the treatment of coronary heart disease.
METHODS: The literatures about domestic and imported rapamycin-eluting stents in the treatment of coronary heart disease are comprehensively searched in accordance with the demands of the evidence-based medicine in the last 5 years. Meta-analysis was conducted on the literatures enrolled.
RESULTS AND CONCLUSION: Totally 16 controlled clinical trials were enrolled, including 2 603 casesundergoing domestic rapamycin-eluting stents and 2 646 cases undergoing imported rapamycin-eluting stents. Meta-analysis results suggested no statistical difference in major adverse cardiac events, target vessel revascularization, cardiac death, myocardial infarction, and stent thrombosis incidence between the domestic and imported rapamycin-eluting stents. It is indicated that from the present clinical trials, domestic rapamycin-eluting stents are not secondary to imported rapamycin-eluting stents in safety and efficacy.

Key words: biomaterials, evidence-based biomaterials, coronary heart diseases, rapamycin-eluting stents, safety, efficacy, major adverse cardiac events, Meta analysis

CLC Number:

R318

Hao Ya-rong, Liu Si-ling, Zhang Li-jun, Li Fang-fang. Medium- and long-term efficacy and safety of domestic and imported rapamycin-eluting stents[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(3): 560-564.

Figures/Tables 9

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