Compound cottonrose hibiscus leaf gel plaster of optimal “Xiaozhongsan” formulation for knee synovitis

doi:10.12307/2024.367

Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (10): 1580-1585.doi: 10.12307/2024.367

Compound cottonrose hibiscus leaf gel plaster of optimal “Xiaozhongsan” formulation for knee synovitis

Yan Wei1, Kong Bo2, Xi Xiaobing1, 3, 4, Xu Yong3, Jia Youji1, Ruan Beite1, 4, Zhang Jiahui1, 3, 4, Ma Honghong1, 3, 4, Li Zhongwei4

1Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2Wuxi Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Wuxi 214100, Jiangsu Province, China; 3Shanghai Key Laboratory of Prevention and Treatment of Bone and Joint Diseases, Shanghai 200025, China; 4Shanghai Institute of Traumatology and Orthopedics, Shanghai 200025, China

Received:2023-03-11 Accepted:2023-05-27 Online:2024-04-08 Published:2023-08-19
Contact: Li Zhongwei, Chief physician, Shanghai Institute of Traumatology and Orthopedics, Shanghai 200025, China
About author:Yan Wei, Master, Physician, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Supported by:
Scientific Research Project of Traditional Chinese Medicine of Shanghai Municipal Commission of Health and Family Planning, No. 2018LP025 (to LZW); Three-Year Action Plan Project for Further Accelerating the Inheritance, Innovation and Development of Traditional Chinese Medicine in Shanghai (2021-2023), No. ZY(2021-2023)-0208 (XXB); Three-Year Action Plan Project for Further Accelerating the Inheritance, Innovation and Development of Traditional Chinese Medicine in Shanghai (2021-2023), No. ZY(2021-2023)-0209-03 (to XXB); Shanghai Young Scientific and Technological Talents Sailing Plan Project, No. 20YF1427400 (to YW); Shanghai Key Clinical Specialty Construction Project, No. SHSLCZDZK04802 (to XXB); “Jiao Tong University Star” Planned Key Medical Engineering Project of Shanghai Jiao Tong University, No. YG2019ZDA16 (to XXB); Shanghai Flagship Hospital Construction Project of Integrated Traditional Chinese and Western Medicine, No. ZY(2021-2023)-0205-01 (to XXB, YW); Shanghai Style TCM School Inheritance and Innovation Team Construction Project, No. 2021LPTD-003 (to XXB)

Abstract

Abstract: BACKGROUND: Previous studies have confirmed that the new compound cottonrose hibiscus leaf gel plaster has a good effect in the treatment of acute soft tissue swelling.
OBJECTIVE: To observe the clinical efficacy of compound cottonrose hibiscus leaf gel plaster in the treatment of synovitis of the knee joint.
METHODS: Seventy-two patients with knee synovitis were selected from Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from December 2019 to May 2021. These patients were randomly divided into a trial group and a control group, with 36 cases in each group. The trial group was treated with compound cottonrose hibiscus leaf gel plaster, once a day, 12 hours each time, while the control group was treated with Diclofenac Diethylamine Emulgel, twice a day. After 28 days of treatment, visual analog scale score, WOMAC Osteoarthritis Index score, quality of life score (SF-36), thickness of knee synovium and comprehensive curative effect were compared between the two groups.
RESULTS AND CONCLUSION: (1) Visual analog scale scores after treatment were lower than those before treatment (P < 0.05). Visual analog scale scores in the trial group after 7, 14 and 28 days of treatment were lower than those in the control group (P < 0.05). The WOMAC Osteoarthritis Index scores of the two groups after treatment were lower than those before treatment (P < 0.05), and the WOMAC Osteoarthritis Index scores in the trial group after 7, 14 and 28 days of treatment were lower than those in the control group (P < 0.05). (3) The SF-36 quality of life score in the two groups after 28 days of treatment was higher than that before treatment (P < 0.05). SF-36 quality of life score in the trial group after 28 days of treatment was higher than that in the control group (P < 0.05). (4) After 28 days of treatment, the thickness of knee synovium in the trial group was less than that in the control group (P < 0.05), and the effective rate in the trial group was higher than that in the control group (P < 0.05). (5) These findings indicate that compared with Diclofenac Diethylamine Emulgel, the compound cottonrose hibiscus leaf gel plaster can better relieve knee pain, enhance knee joint function, reduce synovial hyperplasia, and elevate the overall quality of life of patients.

Key words: knee synovitis, knee osteoarthritis, compound cottonrose hibiscus leaf gel plaster, external treatment, plaster, medicinal treatment

CLC Number:

Yan Wei, Kong Bo, Xi Xiaobing, Xu Yong, Jia Youji, Ruan Beite, Zhang Jiahui, Ma Honghong, Li Zhongwei. Compound cottonrose hibiscus leaf gel plaster of optimal “Xiaozhongsan” formulation for knee synovitis[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(10): 1580-1585.

Figures/Tables 9

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Compound cottonrose hibiscus leaf gel plaster of optimal “Xiaozhongsan” formulation for knee synovitis

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