Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (27): 4356-4363.doi: 10.3969/j.issn.2095-4344.2717

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Concept, mechanism and problem of gene therapy for osteoarthritis

Hu Zhongling1, Li Binbin1, Cui Yishuang2, Wang Qian2, Zhang Hui3, Li Qijia2, Wang Zhiqiang1   

  1. 1Department of Orthopedics, Affiliated Hospital, North China University of Science and Technology, Tangshan 063000, Hebei Province, China; 2Medical Experimental Research Center of North China University of Science and Technology, Tangshan 063000, Hebei Province, China; 3First Department of Arthrology, Tangshan Second Hospital, Tangshan 063000, Hebei Province, China
  • Received:2019-11-16 Revised:2019-11-20 Accepted:2020-01-02 Online:2020-09-28 Published:2020-09-09
  • Contact: Wang Zhiqiang, Chief physician, Professor, Doctoral supervisor, Department of Orthopedics, Affiliated Hospital, North China University of Science and Technology, Tangshan 063000, Hebei Province, China
  • About author:Hu Zhongling, Master candidate, Department of Orthopedics, Affiliated Hospital, North China University of Science and Technology, Tangshan 063000, Hebei Province, China
  • Supported by:
    the National Science and Technology Support Program, No. 2012BAE06B03; the Hebei Science and Technology Support Project, No. 16277776D; the Key Support Project of Hebei Province Medical Science Research, No. 20160225

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Abstract:

BACKGROUND: Specific gene expression at specific injury sites enhances cell regeneration.

OBJECTIVE: To summarize the concept of gene therapy, to review the strategies of gene therapy and the mechanism of gene therapy for osteoarthritis, and to introduce the research direction of gene therapy.

METHODS: Extensive consulted the literature on osteoarthritis gene therapy and related content in foreign databases such as PubMed and Science Direct. The key words were “Gene therapy, Cartilage, Cartilage repair, Osteoarthritis, Expression vectors, miRNA”. Above data were analyzed and summarized.

RESULTS AND CONCLUSION: Gene therapy for osteoarthritis can be applied to all aspects of the pathogenesis of osteoarthritis and affect the metabolism of related substances. The target gene is delivered to



the target cells through viral or non-viral vectors. At present, the focus of gene therapy is to accelerate cell repair and reduce inflammatory response. At the same time, multiple choices of gene vectors and target genes provide better individualized treatment options. The specific mechanism of gene therapy for osteoarthritis in clinic is not clear, and there is the possibility of gene mutation, which needs to be further studied to verify the safety.

Key words: gene therapy, osteoarthritis, miRNA, growth factor, viral vector

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