Low-intensity pulsed ultrasound can alleviate knee osteoarthritis pain and promote articular cartilage repair

doi:10.3969/j.issn.2095-4344.0601

Abstract

Abstract:

BACKGROUND: Low-intensity pulse ultrasound (LIPUS) has been shown to effectively alleviate joint swelling and inflammation in patients with knee osteoarthritis. But its efficacy in the alleviation of osteoarthritis pain and in the repair of articular cartilage is rarely reported.
OBJECTIVE: To evaluate the effect of LIPUS on alleviating knee osteoarthritis pain and treating articular cartilage injury.
METHODS: Totally 120 patients with knee osteoarthritis were randomly divided into three groups, and treated with diclofenac sodium sustained release tablets (control group), LIPUS (LIPUS group) and their combinations (combination group), respectively. The visual analogue scale, Lequence index, Lysholm score, Noyes score, clinical efficacy and adverse reactions were observed at 1 and 3 months after treatment.
RESULTS AND CONCLUSION: At 1 and 3 months after treatment, in the LIPUS and combination groups, the visual analogue scale score and the Lequence index were significantly lower than those in the control group, and the total effective rate was significantly higher than that in the control group (P < 0.01, P < 0.05). At 1 and 3 months after treatment, the Lysholm scores in the LIPUS and combination groups were significantly higher than those in the control group (P < 0.01). The Noyes scores in the LIPUS and combination groups were significantly lower than those in the control group at 1 and 3 months after treatment (P < 0.01). Additionally, there were two cases of drug-related headache and nausea in the control group, and no ultrasonic toxicity or drug-related adverse events occurred in the other two groups. These results imply that LIPUS is effective in the treatment of knee osteoarthritis, can effectively relieve pain and promote the repair of articular cartilage injury. It shows no effect on the effectiveness of drugs.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Ultrasonic Therapy, Osteoarthritis, Analgesia, Knee Joint, Tissue Engineering

CLC Number:

R454.3

Luo Xianwen, Li Mingxing. Low-intensity pulsed ultrasound can alleviate knee osteoarthritis pain and promote articular cartilage repair[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(3): 348-353.

Figures/Tables 6

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