Pelvic floor reconstruction using Gynemesh

doi:10.3969/j.issn.2095-4344.2016.34.016

Abstract

Abstract:

BACKGROUND: Gynemesh is a polypropylene fabric woven by monofilament polypropylene shaped into a flat form, with a strong tensile strength, small foreign body reaction and good biocompatibility.
OBJECTIVE: To investigate the effect of Gynemesh on pelvic floor reconstruction.
METHODS: Gynemesh was prepared by the chemical reduction method in the liquid-phase, and observed histologically. Then its thickness, elongation at break, tensile strength, and elasticity modulus were detected. Eight female New Zealand rabbits were used to make pelvic floor dysfunction models by a vaginal balloon, and randomly assigned into experimental group (pelvic floor reconstruction using Gynemesh) or control group (vaginal wall repair and hysterectomy), respectively. Thirty days post surgery, the Pelvic Floor Impact Questionnaire (PFIQ-7) and Pelvic Floor Distress Inventory (PFDI-20) were detected and compared between two groups.
RESULTS AND CONCLUSION: The Gynemesh had a thickness of (0.37±0.14) mm, an elongation at break of (25.35±2.68)%, a tensile strength of (7.69±1.17) MPa, and an elastic modulus of (0.007±0.008) GPa. Under the light microscope, a large amount of pink collagen fibers arranged neatly on the Gynemesh, but no blue nuclear material and residual cells existed. Under the scanning electron microscope, the fibers were tightly packed with no residual cells on the Gynemesh. At 30 days after surgery, the Gynemesh was not degraded and no erosion reaction occurred in the experimental group. Moreover, the experimental group had a lower incidence of complications compared with the control group (P < 0.05). These findings indicate that the Gynemesh has good biological performance and it is an ideal material for pelvic floor reconstruction.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

CLC Number:

R318

Yang Lan, Wang Juan, Xu Lan-lan, Wang Li-feng, Li Yan-fang. Pelvic floor reconstruction using Gynemesh[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(34): 5116-5121.

Figures/Tables 2

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