Alveolar bone defect repair using autologous bone marrow mesenchymal stem cells combined with platelet-rich fibrin

doi:10.3969/j.issn.2095-4344.2016.01.001

Abstract

Abstract:

BACKGROUND: Alveolar bone deficiency will not meet aesthetic and functional requirements for dental implants.

OBJECTIVE: To observe the repair effect of passage 3 autologous bone marrow mesenchymal stem cells (BMSCs) and platelet-rich fibrin (PRF) on alveolar bone defects in rabbits.

METHODS: Twenty-seven New Zealand rabbits were randomly divided into BMSCs/PRF group, PRF group and model group (n=9 per group). The left mandible incisors were extracted in all the rabbits under general anesthesia. BMSCs/PRF group was immediately implanted BMSCs/PRF composite into the alveolar socket, PRF group only implanted PRF, and model group implanted nothing.

RESULTS AND CONCLUSION: In the model group, the alveolar crest and alveolar mucosa become sunken notably and narrowed. In the BMSCs/PRF and PRF groups, the thickness of alveolar bone wall, alveolar bone width, alveolar bone height difference, and bone mineral density were all increased, especially in the former group. In addition, the trabecular arrangement was better in the BMSCs/PRF groups than the model and PRF group. Our findings indicate that alveolar socket filling with composite of BMSCs and PRF can achieve preservation of alveolar bone width and height after tooth extraction in rabbits.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

CLC Number:

R394.2

Li Shu-hui, Dai Xiao-wei, Zhang Wen-li, Chen Cheng, Wu Pei-ling. Alveolar bone defect repair using autologous bone marrow mesenchymal stem cells combined with platelet-rich fibrin[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2016.01.001.

Figures/Tables 3

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