Fertilization failure following intracytoplasmic sperm injection: causes and countermeasures

doi:10.3969/j.issn.2095-4344.2015.51.026

Abstract

Abstract:

BACKGROUND: Intracytoplasmic sperm injection (ICSI) has become the first choice for treatment of male infertility. Despite its high success rates, fertilization failure following ICSI still occurs in 1%-3% of couples.
OBJECTIVE: To review the relevant factors and countermeasures of fertilization failure in ICSI.
METHODS: Wanfang, CNKI and PubMed databases were searched for articles related to ICSI published from January 1994 to June 2015. Finally, 60 articles meeting the inclusive criteria were included in result analysis.
RESULTS AND CONCLUSION: Oocyte activation failure is closely related to abnormal eggs, sperm defects, age, micromanipulation technology and laboratory environment. Assisted oocyte activation is the gordian technique to solve the fertilization failure in ICSI. To understand the reasons for fertilization failure in ICSI and to take appropriate measures can promote the rate of fertilization and improve the potential of embryonic development.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

CLC Number:

R318

Tang Yong-mei, Wei Ji-hong. Fertilization failure following intracytoplasmic sperm injection: causes and countermeasures[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(51): 8344-8351.

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