Effects of cyclooxygenase inhibitors on nuclear factor κB and CD4+/CD8+ expression in rat models of acute incomplete spinal cord injury

doi:10.3969/j.issn.2095-4344.2015.49.007

Abstract

Abstract:

BACKGROUND: Celecoxib has advantages including fewer adverse reactions and low cost over the commonly used methylprednisolone in the treatment of acute spinal cord injury, but the effective dose cannot be well controlled.
OBJECTIVE: To investigate different doses of cyclooxygenase inhibitors on nuclear factor κB and CD4+/CD8+ expression in rat models of acute incomplete spinal cord injury.
METHODS: Rat models of incomplete spinal cord injury in T8 and T9 segments were established using modified Allen method. Sixty successful modeling rats were randomly and evenly divided into 4 groups: simple injury group and low, medium-and high-dose of celecoxib groups. Rats in simple injury group were not applied any drugs. Rats in low-, medium- and high-dose celecoxib groups were respectively intragastrically administered 25, 50 and 100 mg/kg celecoxib after 30 minutes of spinal cord injury.
RESULTS AND CONCLUSION: After celecoxib treatment, rat neurological function was significantly improved. Nuclear factor κB expression level in spinal cord was significantly decreased. CD4+ and CD8+ T cell numbers in peripheral blood were significantly decreased. Low dose of celecoxib treatment had a better outcome. These results suggest that different doses of celecoxib can treat acute traumatic spinal cord injury, and low-dose
(25 mg/kg) celecoxib treatment can achieve a better outcome.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

CLC Number:

R318

Xin Zhi-qiang, Pan Meng, Wang Jing-liang, Zheng Quan-xin, Xu Yi-dong, Pi An-ping. Effects of cyclooxygenase inhibitors on nuclear factor κB and CD4+/CD8+ expression in rat models of acute incomplete spinal cord injury [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(49): 7908-7913.

Figures/Tables 5

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