Co-transplantation of acellular allogeneic dermis and autologous split-thickness skin for burn repair at functional parts

doi:10.3969/j.issn.2095-4344.2015.29.012

Abstract

Abstract:

BACKGROUND: Autologous split-thickness skin grafting is the main therapy for burn repair at functional sites, which has achieved certain effects, but there are still some deficiencies, such as poor texture, stiffness and poor toughness, as well as severer hyperplasia that is easy to result in contracture deformity and poor functional recovery.
OBJECTIVE: To analyze the clinical efficacy of skin co-transplantation on burn repair at functional sites.
METHODS: Sixty patients with burns at functional sites (n=84) were randomized into two groups: co-transplantation of acellular dermis and autologous split-thickness skin in experimental group and autologous split-thickness skin graft in control group. Survival rate of skin flap and rate of secondary operation were compared between two groups. At 1 month after transplantation, Vancouver Scar Scale was used to assess skin color, thickness, blood vessel distribution and flexibility, and meanwhile, the severity of scar was determined.
RESULTS AND CONCLUSION: The survival rate of skin flap was significantly higher in the experimental group than the control group (93% vs. 70%, P < 0.05), and the rate of secondary operation was significantly lower in the experimental group compared with the control group (0 vs. 13%, P < 0.05). At 1 month after transplantation, scores on the skin color, thickness, blood vessel distribution and flexibility were all lower in the experimental group than the control group (P < 0.05), but the incidence of mild hyperplasia in the experimental group was significantly higher than that in the control group (52% vs. 29%, P < 0.05). These findings indicate that co-transplantation of acellular allogeneic dermis and autologous split-thickness skin for burn repair at functional sites can effectively enhance the survival rate of skin flap, reduce the rate of secondary operation, contribute to wound healing and reduce the severity of hyperplasia.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Cicatrix, Burns, Transplantation

CLC Number:

R318

Ke Chang-neng, Liu Po, Chen Jie-ming, Li Yan-hua, Liang Da-ning . Co-transplantation of acellular allogeneic dermis and autologous split-thickness skin for burn repair at functional parts [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(29): 4652-4656.

Figures/Tables 2

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