Application of novel materials in tissue repair of diabetic foot wounds

doi:10.12307/2026.886

Abstract

Abstract: BACKGROUND: In recent years, the convergence of materials science and biomedical engineering has opened new avenues for diabetic foot wound treatment. Novel biomaterials such as multifunctional hydrogels, tissue engineering scaffolds, and nanoparticle systems have become a research hotspot.
OBJECTIVE: To analyze, through bibliometric analysis, the design principles and biological functions of novel materials used in diabetic foot wound treatment, their potential in addressing the complex pathological challenges of diabetic foot, and to forecast future directions and challenges in this field.
METHODS: We searched the Web of Science database for literature on novel materials for diabetic foot wound treatment from its inception until June 2025. CiteSpace software was used for bibliometric and visual analysis.
RESULTS AND CONCLUSION: From 1979 to 2025, the publication output in the field of novel materials for treating diabetic foot ulcers showed an overall fluctuating upward trend, with an explosive growth period observed between 2022 and 2025. The United States had the highest number of publications (602), followed by China (284) and India (166). Among institutions, Sichuan University had the highest publication volume, followed by Tehran University of Medical Sciences. Ranked by the total influence of publications, Sichuan University ranked first, followed by Nankai University. Among hospitals, West China Hospital had the highest publication count, followed by Beth Israel Deaconess Medical Center and Thomas Jefferson University Hospital. Ranked by the influence of publications, West China Hospital remained first, followed by Shanghai Ninth People’s Hospital and Thomas Jefferson University Hospital. Among enterprises/groups, Success Bio-Tech Co. Ltd., Engineering Software Research and Development Inc., and Foot and Ankle Associates of Central Illinois LLC were tied for first place in publication count (each with 2 publications). Ranked by influence, Organogenesis Inc. had the highest influence, followed by Food Industry Research Co. Among journals, Wounds had the highest number of publications (96), followed by Foot Ankle Int (40) and Cureus (38). Among authors, Bus, Sicco A. had the most publications (12), followed by Lázaro-Martínez, José Luis (8). Ranked by publication influence, the GBD 2021 collaborative research groups (including the US Burden of Disease and Forecasting Collaborators, Diabetes Collaborators, Obesity Collaborators, Adult and Adolescent BMI Collaborators, Causes of Death Collaborators, etc.) had the highest influence.

Key words: diabetic foot, diabetic foot wound, diabetic foot ulcer, biomaterials, dressings, visualization analysis

CLC Number:

Xia Jinyan, Su Meifang, Yang Wenyu, Hu Qilan, Gong Li. Application of novel materials in tissue repair of diabetic foot wounds[J]. Chinese Journal of Tissue Engineering Research, 2026, 30(32): 8563-8568.

Figures/Tables 9

References

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