Percutaneous kyphoplasty combined with 125I for treatment of metastatic spinal tumors

doi:10.3969/j.issn.2095-4344.2014.03.007

Abstract

Abstract:

BACKGROUND: Radiotherapy alone is not suitable for tumor-caused vertebral fractures and neurological dysfunction. In recent years, ¹²⁵I radiation particles have been widely used in a variety of primary or secondary tumors and achieved good results. Percutaneous kyphoplasty can restore vertebral height efficiently, remodel spinal stability, and relieve pain.
OBJECTIVE: To evaluate safety and effectiveness of percutaneous kyphoplasty combined with ¹²⁵I in patients with metastatic spinal tumors.
METHODS: A retrospective study was conducted to review 30 cases of metastatic spinal tumors undergoing percutaneous kyphoplasty combined with¹²⁵I from March 2011 to July 2012. Symptoms, signs, and imaging findings were collected and analyzed. All the patients had a refractoriness back pain. CT scan showed osteolytic changes in the vertebrae. The visual analogue scales, WHO standards for pain relief and Owestry disability index
were recorded to analyze the clinical symptoms outcome and recovery of neurological function, and the change of height in abnormal vertebrae was measured. The follow-up time was 1 day, 1 month and 6 months postoperatively.
RESULTS AND CONCLUSION: Operations in all the 30 patients were done successfully. All patients got a conspicuous pain relief in 24 hours after operation, and nospinal injury or compression was found. There were significant differences in scores of visual analogue scales, pain levels, Owestry disability index, and the height of vertebral bodies before and after operation (P < 0.05). During postoperative follow-up of 1 and 6 months, scores of visual analogue scales, pain levels, Owestry disability index, and the height of vertebral bodies showed no difference from those at 24 hours postoperatively (P > 0.05). Bone cement leakage occurred in the anterior longitudinal ligament (n=2) and intervertebral space (n=2), and no serious complications occurred. Percutaneous kyphoplasty combined with ¹²⁵I is a safe and effective way to treat metastatic spinal tumors, which can quickly ease the pain caused by spinal tumor, recover the abnormal vertebral height, reduce complications and improve life quality of patients.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: kyphoplasty, spine, neoplasms, pain, back pain

CLC Number:

R318

Zhang Wei, Shi Jian-dang, Niu Ning-kui, Zhang Jun-shan, Geng Guang-qi. Percutaneous kyphoplasty combined with ¹²⁵I for treatment of metastatic spinal tumors [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(3): 371-376.

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Percutaneous kyphoplasty combined with ¹²⁵I for treatment of metastatic spinal tumors

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