Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (22): 4080-4083.doi: 10.3969/j.issn.1673-8225.2012.22.021

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Acute-stage microcirculation changes of lumbar spine vertebral bone marrow after radiotherapy with magnetic resonance perfusion-weighted imaging

Xie Feng, Pan Shi-nong, Wang Feng-zhe, Fu Xi-hu, Liu Nan, Guo Qi-yong   

  1. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang  110004, Liaoning Province, China
  • Received:2012-02-07 Revised:2012-04-06 Online:2012-05-27 Published:2012-05-27
  • Contact: Pan Shi-nong, Doctor, Professor, Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China cjr.panshinong@vip.163.com
  • About author:Xie Feng☆, Doctor, Attending physician, Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China allenxie2006@163.com
  • Supported by:

    Scientific Research Foundation of the Higher Education Institutions of Liaoning Educational Committee in 2009, No.2009T098*

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Abstract:

BACKGROUND: The study of the shortly change of microcirculation after lumbar radiotherapy using magnetic resonance perfusion-weighted imaging is significant to research lumbar micro-cycle characteristics, the development of radiation treatment planning, as well as to determine the disease prognosis.
OBJECTIVE: To investigate the acute-stage microcirculation changes of lumbar spine vertebral bone marrow in rabbit after radiotherapy with magnetic resonance perfusion-weighted imaging.
METHODS: Fifteen rabbits were divided into 3 groups and underwent dynamic contrast enhanced magnetic resonance imaging of the lumbar spine. After 24 hours, local radiotherapy of the lumbar spine was performed, each rabbit underwent radiotherapy on lumbar spine by different X-ray doses (500 cGy, 1 000 cGy, 1 500 cGy). Seven days after the radiotherapy, each subject re-underwent dynamic contrast enhanced magnetic resonance imaging of the lumbar spine. The changes of the maximum enhancement value, peak enhancement rate and the wash-in rate were analyzed with the time-intensity curve.
RESULTS AND CONCLUSION: The maximum enhancement value in the group with 500 cGy was increased after radiotherapy  (P < 0.05). The maximum enhancement value and the wash-in rate in the group with 1 000 cGy were increased after radiotherapy (P < 0.05). The maximum enhancement value, peak enhancement rate and the wash-in rate in the group with 1 500 cGy were increased after radiotherapy (P < 0.05). It can be observed using dynamic contrast-enhanced magnetic resonance perfusion imaging that the acute-stage changes of the microcirculation of rabbit lumbar spine vertebral bone marrow is ascended after radiotherapy, and in a dose-dependent manner.

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