Abstract:

BACKGROUND: The author plans to investigate whether prosthesis design of hip surface replacement reaches mature, and whether causes femoral head necrosis by establishing animal models.
OBJECTIVE: To observe the histological changes of normal femoral head after femoral head surface replacement through the experimental study of the New Zealand rabbits.
METHODS: Sixty healthy rabbits had undergone left femoral head surface replacement, and the right side served as the normal control group. They were killed at time intervals of 3, 6, 9 and 12 weeks to remove the femoral head. Macroscopic, light microscopy, scanning electron microscope had used to observe the removed femoral head.
RESULTS AND CONCLUSION: After the femoral head surface replacement, a small region of bone necrosis, granulation tissue hyperplasia fibrosis and bone resorption were found at the bone-cement interface. At the bone-implant interface, a smaller region of bone necrosis and granulation tissue hyperplasia fibrosis were also found, but without bone resorption. In the region of far from cement and implant, neither bone necrosis nor bone resorption was found. The pathological character was same to the healthy bone. This histological evaluation indicated that femoral head surface replacement cannot cause femoral head necrosis, and there is no cause and effect relationship between operation type, implant and femoral head necrosis, which confirmed the security and superiority of the femoral head surface replacement for the treatment of hip disease.