Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (19): 3598-3601.doi: 10.3969/j.issn.1673-8225.2012.19.035

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Differentiation of mesenchymal stem cells into cardiac-like cells

Zhu Sha, Sun Jie, Ling Bin   

  1. The Forth Affiliated Hospital of Kunming Medical University, Kunming  650021, Yunnan Province, China
  • Received:2011-09-21 Revised:2011-10-15 Online:2012-05-06 Published:2012-05-06
  • Contact: Ling Bin, Professor, Chief physician, Master’s supervisor, the Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China Lingbin02@yahoo.com
  • About author:Zhu Sha★, Studying for master’s degree, Physician, the Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China snowmoonstar@163.com
  • Supported by:

    the Natural Science Foundation of Yunnan Province, No. 2010ZC220*

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Abstract:

BACKGROUND: At present, many experiments have shown that mesenchymal stem cells (MSCs) can differentiate into cardiac-like cells or cardiocytes in vitro and in vivo. This makes it possible for MSCs in treatment of cardiac diseases.
OBJECTIVE: To compare the laboratory methods and existing problems of differentiation of MSCs into cardiac-like cells.
METHODS: A computer-based online search of PubMed database and Wanfang database from December 2000 to December 2010 was performed for relative articles about differentiation of MSCs into cardiac-like cells, with key words of “mesenchymal stem cells, cardiomyocyte, differentiation” in English and in Chinese.
RESULTS AND CONCLUSION: The main methods for differentiation of MSCs into cardiac-like cells: (1) conditioned medium: MSCs can be induced to differentiate into cardiocytes in vitro using drugs or in simulated cardiac microenvironment; (2) co-culture with the objective cells: MSCs can be induced to differentiate into cardiocytes using drugs or in cardiac microenvironment without induction. MSCs can differentiate into cardiocytes under cardiac pathological condition, and it makes possible for MSCs in treatment of cardiac diseases, however, more studies are required to improve this.

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