Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (11): 1923-1926.doi: 10.3969/j.issn.1673-8225.2012.11.006

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Effects of Wenyang Huoxue recipe on transforming growth factor beta/Smad signal transduction pathway in model rats of renal interstitial fibrosis 

Hu Shao-jin1, Li Jun2   

  1. 1Department of Rehabilitation, the Central Hospital of Shaoyang, Shaoyang  422000, Hunan Province, China; 2Department of Traditional Chinese Medicine, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai  519000,  Guangdong Province, China
  • Received:2011-07-08 Revised:2011-10-19 Online:2012-03-11 Published:2012-03-11
  • Contact: author: Li Jun, Doctor, Chief physician, Master’s supervisor, Department of Traditional Chinese Medicine, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai 519000, Guangdong Province, China lijun69-1214@163.com
  • About author:Hu Shao-jin★, Master, Department of Rehabilitation, the Central Hospital of Shaoyang, Shaoyang 422000, Hunan Province, China Hushaojin2006@yahoo.com.cn
  • Supported by:

    the Foundation of Governor of Guizhou Province, No. C-263*; the Staring Foundation for Doctors of Zunyi Medical College, No.2004-007*

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Abstract:

BACKGROUND: Transforming growth factor β/Smad signal transduction pathway plays an important role in the occurrence and development of renal fibrosis.
OBJECTIVE: To investigate the effects of Wenyang Huoxue recipe on transforming growth factor β/Smad signal transduction pathway in renal interstitial fibrosis rats.
METHODS: A total of 28 male SD rats of clean grade were randomly assigned into sham operation group and model group. Left urethral ligation was performed in rats to construct unilateral ureteral obstruction model. The left ureter of sham operation rats was isolated without ligation after opening the abdominal cavity; then the abdominal cavity was closed. The rats were administrated with Wenyang Huoxue recipe by gavage once. Rats in both groups were administered by gavage for 14 days. RESULTS AND CONCLUSION: The expression of transforming growth factor β1 and Smad3 in the Wenyang Huoxue group was significantly lower than that in the model group (P < 0.01). The expression of Smad7 in the Wenyang Huoxue group was significantly larger than that in the model group (P < 0.01) and similar to that in the fosinopril group. It is conjectured that Wenyang Huoxue recipe may inhibit the expression of transforming growth factor β1 and Smad3, increase Smad7 expression, thereby affecting the transforming growth factor β/Smad signaling pathway, and thus play a role in the prevention and cure of renal interstitial fibrosis.

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