Abstract:

BACKGROUND: Repair of alveolar cleft is an important part of treatment of cleft lip and palate. Composite artificial bone prepared by optimal combination based on the carrier of artificial bone has a highly osteoinductive activity and can greatly improve the treatment effect in repair of bone defects in clinic.
OBJECTIVE: To evaluate the combined effects of bone morphogenetic protein-2 (BMP-2) and β–tricalcium phosphate (β-TCP) in alveolar cleft reconstruction.
METHODS: Twenty-four alveolar cleft patients from Department of Stomatology, Lianyungang Second People’s Hospital were divided into experimental group and control group randomly. The experimental group was repaired with BMP-2/β-TCP. The control group was repaired with autogenous iliac cancellous bone.
RESULTS AND CONCLUSION: Incisions in both groups were with primary healing and without implant extrusion. All of the patients were followed-up for 3-6 months. Three months after surgery, bone concrescence was seen on X-ray. Part of the artificial bone was replaced by autologous bone and the bone resorption was not obvious in the experimental group after 1 year of surgery, while the bone resorption in the control group was obvious. Enemar grading standard showed that the efficacy rates of grade Ⅰ in the experimental group and control group were 84% and 17% respectively, and the difference was significant (P < 0.05). It is indicated that the granulo-β-TCP/BMP-2 has the advantages of an accurate shape recovery and a low repair trauma in alveolar cleft reconstruction; the implant has a good biocompatibility, osteocondutibility and degradability, so as can be completely replaced by autologous bone and well used in alveolar cleft reconstruction.