Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9518-9522.doi: 10.3969/j.issn.1673-8225.2011.51.005

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Effect of zinc on titanium implant bone fusion

Chen Hai-jun1, Zhang An-sheng2, Lin Jun-zhou1, Qian Qi-chun1, Yu Shu-xiang1, Nan Fu-qing1   

  1. 1Department of Stomatology, the 97 Hospital of Chinese PLA, Xuzhou  221004, Jiangsu Province, China
    2Health Team of the 73085 Troop of Chinese PLA, Xuzhou  221011, Jiangsu Province, China
  • Received:2011-05-25 Revised:2011-07-21 Online:2011-12-17 Published:2011-12-17
  • About author:Chen Hai-Jun★, Master, Associate chief physician, Department of Stomatology, the 97 Hospital of Chinese PLA, Xuzhou 221004, Jiangsu Province, China chjchjcc@163.com

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Abstract:

BACKGROUND: Previous research has testified that zinc can improve the healing rate and enhance the fixation strength of implants.
OBJECTIVE: To observe the effect of zinc on the morphology of implant-bone interface.
METHODS: Forty adult male rabbits were involved and divided into zinc supplement group and control group. The titanium implants were implanted into bilateral tibias at the proximal end to establish animal models of titanium implants. Zinc sulfate of 10 g/L was administered intramuscularly to the animals in the zinc supplement group at the dose of 4 mg/kg once per day, and those in the control group were treated with saline at the same dose. The animals were killed at 1, 2, 4, 8 and 12 weeks after treatment. Stereomicroscope and scanning electron microscopy were used to observe the morphology of the implant-bone interface.
RESULTS AND CONCLUSION: Zinc supplement could accelerate the new bone formation on the implant-bone interface at 1-4 weeks after treatment to facilitate the fusion between the implant and bone. It is indicated that amount of zinc supplement can promote the new bone formation and enhance the speed and quality of bone healing.

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