Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (48): 9116-9120.doi: 10.3969/j.issn.1673-8225.2011.48.047

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Variation in serum biomarkers of bone turnover in rapidly progressive necrosis of the femoral head

Mei Jie1, Peng Hao1, Yin Dong2   

  1. 1Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan  430060, Hubei Province, China
    2Department of Orthopedics, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-06-14 Revised:2011-09-01 Online:2011-11-26 Published:2011-11-26
  • Contact: Peng Hao, Doctor, Professor, Doctoral supervisor, Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China penghao5868@163.com Correspondence to: Yin Dong, Doctor, Chief physician, Master’s supervisor, Department of Orthopedics, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China tangin2002@163.com
  • About author:Mei Jie★, Studying for master’s degree, Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China meijie302@yahoo.com.cn

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Abstract:

BACKGROUND: Foreign studies have suggested that the pathogenesis of rapidly progressive necrosis of the femoral head is associated with abnormal serum metabolism of articular cartilage and osteoclast dysfunction.
OBJECTIVE: To determine the expression of TRACP-5b and CTX-Ⅱ in serum of patients with rapidly progressive necrosis of the femoral head.
METHODS: Enzyme-linked immunosorbent assay kit was used to detect the expression of TRACP-5b and CTX-Ⅱ in serum of patients with common femoral head necrosis (group A, n=30), patients with rapidly progressive femoral head necrosis (group B, n=30), patients with osteoporosis (group C, n=30), and patients with Soft tissue defect or simply popliteal cyst (group D, n=30).
RESULTS AND CONCLUSION: The expressions of TRACP-5b in the groups B and C were higher than those in the groups A and D (P < 0.05); while the expression of TRACP-5b was slightly higher in the group C than the group D without significant difference (P >0.05). The expressions of CTX-Ⅱ was the highest in the group B (P < 0.05), and slightly higher in the groups A, C than group D without significant difference (P > 0.05). It is indicated that one of the possible pathological mechanisms of the rapidly progressive necrosis of the femoral head is the enhance activity of osteoclasts leading to the elevated expression of serum TRACP-5b and rapid articular cartilage degradation leading to the elevated expression of serum CTX-Ⅱ. The candidate diagnostic criteria for the rapidly progressive necrosis of the femoral head may be the TRACP-5b and CTX-Ⅱ in the future.

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