Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (48): 9027-9030.doi: 10.3969/j.issn.1673-8225.2011.48.024

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Assessment of 18F-fluorodeoxyglucose uptake in different organs detected with positron emission tomography/CT in healthy adults during fasting

Xu Yu1,2, Li Ai-mei3, Guo Wan-hua3, Hu Yun1   

  1. 1Department of Endocrinology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing  210008, Jiangsu Province, China; 2People's Hospital of Tongzhou District, Nantong  226300, Jiangsu Province, China; 3Department of Nuclear Medicine, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing  210008, Jiangsu Province, China
  • Received:2011-04-01 Revised:2011-10-08 Online:2011-11-26 Published:2011-11-26
  • Contact: Hu Yun, Master’s supervisor, Professor, Department of Endocrinology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China huyundr@gmail.com
  • About author:Xu Yu★, Master, Department of Endocrinology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China; People's Hospital of Tongzhou District, Nantong 226300, Jiangsu Province, China uuxy@sohu.com
  • Supported by:

    Nanjing Medical Key Technology Development Project, No. ZKX10016*

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Abstract:

BACKGROUND: Previous studies in home and aborad were mainly focus on glucose uptake of cancer patient in vivo, but few studies for glucose intake in different organs of normal people under fasting.
OBJECTIVE: To observe 18F-fluorodeoxyglucose (FDG) uptake of different organs in healthy adults under fasting by using positron emission tomography (PET)/CT and to analysis the correlation of glycometabolism and healthy adults with brain, liver, kidney, heart and skeletal muscle tissue.
METHODS: Totally 31 healthy adults were treated with liver and kidney functions, blood glucose and triglyceride conventionally test under fasting. Mean and maximum standardized uptake value (SUV) of 18F-FDG with brain, heart, liver, kidney and skeletal muscle were detected by combined PET/CT scanner.
RESULTS AND CONCLUSION: Under fasting, SUV mean of 18F-FDG in brain was two or three times larger than that in heart and kidney, about four times larger than that in liver and 15 times larger than that in skeletal muscle. There were significant positive interrelationships of SUV mean among skeletal muscle, kidney and liver (r=0.406, 0.391, P=0.023, 0.030), but the SUV mean in kidney was no correlation with the heart and brain. It is indicated that under fasting, the quantity of glucose uptake of brain is greater, while of skeletal muscle is fewer, and of heart, liver, kidney is between the brain and the skeletal muscle tissue. There is a significant correlation of glycometabolism among liver, kidney and skeletal muscle under fasting.

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