Abstract:

BACKGROUND: Repairing cranial and maxillofacial bone defect with tissue-engineered bone can solve the problem of lacking bone source and promote the culture of tissue-engineered bone and assist in repairing bone defects using gene therapy.
OBJECTIVE: To summarize the related factors of cranial and maxillofacial bone defect repair and introduce the research progress in this type of factors, providing reference evidence for repairing cranial and maxillofacial bone defect using tissue-engineered
METHODS: Taking “tissue engineering, bone defect, gene therapy, growth factor” as key words, a computer-based online retrieval was performed to search papers published between January 2000 and January 2011 in PubMed and CBM databases in English and Chinese. Papers regarding related factors of cranial and maxillofacial bone defect repair were included and papers with repeated contents were excluded.
RESULTS AND CONCLUSION: A total of 670 papers were initially retrieved. According to inclusion and exclusion criteria, 33 papers were included in the final analysis. There are more and more causes for cranial and maxillofacial bone defects and lacking bone source is a primary problem of restricting cranial and maxillofacial bone defect repair. In vitro construction of tissue-engineered bone is a primary method for solving this problem. Cranial and maxillofacial bone formation involves selection of related factors and construction of tissue-engineered bone, and multi-gene therapy is a promising method.