Abstract:

BACKGROUND: In recent years, with the development of organ transplant technology in clini, osteonecrosis of the femoral head caused by corticosteroids accounts for the first place that has an increased trend year after year.
OBJECTIVE: To review the mechanism of statins drugs in the treatment of osteonecrosis of the femoral head providing the foundation for further experimental research and clinical application.
METHODS: The first author searched CNKI, PubMed, Wanfang and VIP databases in 1980-01/2010-12 to retrieve articles about the mechanism of statins used in the treatment of avascular necrosis of the femoral head. The keywords were “avascular necrosis of the femoral head; statins; glucocorticoids; osteoblast” or “ONFH; corticosteroids; statins; osteoblasts” in Chinese and English, respectively. Articles published recently or in authorized journals were preferred. Old and repetitive experimental articles were eliminated, 169 articles were checked; and according to inclusion criteria, 34 articles were reviewed.
RESULTS AND CONCLUSION: Osteonecrosis of the femoral head is a common and multiple diseases in the field of orthopedics, and its treatment is a difficult task facing the world. Research shows that statins can effectively correct lipid metabolism disorders, reduce bone cell damage in the femoral head, and slow or stop the pathological process of osteonecrosis, deformation and collapse.