Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (43): 8104-8107.doi: 10.3969/j.issn.1673-8225.2011.43.030

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Unilateral versus bilateral kyphoplasty for osteoporotic vertebral compression fractures: A Meta-analysis

Li Da-gang1,2, Su Pei-ji2, Chen Gan-feng2, Chen Shi-zhong2, Gao Heng2   

  1. 1Guangzhou University of Chinese Medicine, Guangzhou  510405, Guangdong Province, China
    2Department of Orthopedics, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Guangzhou  528401, Guangdong Province, China
  • Received:2011-07-21 Revised:2011-08-24 Online:2011-10-22 Published:2011-10-22
  • About author:Li Da-gang☆, Studying for doctorate, Attending physician, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; Department of Orthopedics, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Guangzhou 528401, Guangdong Province, China zsortho@163.com

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Abstract:

BACKGROUND: Kyphoplasty has been shown to significantly improve the treatment of osteoporotic vertebral compression fractures; however, it is still a controversy as to whether the procedure should be done by unilateral or bilateral approach.
OBJECTIVE: To compare the efficacy and safety of unilateral or bilateral kyphoplasty for the treatment of osteoporotic vertebral compression fractures.
METHODS: All controlled studies of unilateral or bilateral kyphoplasty for the treatment of OVCF were identified. Two reviewers assessed the trials and extracted data independently.
RESULTS AND CONCLUSION: Five studies including 241 patients met the inclusion criteria. There was no significant difference between the two groups with regard to improvement in pain and cement leakage (P=0.99, P=0.56, respectively). Compared with unilateral kyphoplasty, kyphotic wedge angle reduction was more significant in the bilateral group (P=0.05). The mean operation time for the unilateral group was significantly shorter than the bilateral group (P < 0.000 01). The results showed that both unilateral kyphoplasty and bilateral kyphoplasty can achieve satisfactory clinical and radiographic outcomes in treating osteoporotic vertebral compression fractures. Although the bilateral kyphoplasty is more efficacious in kyphotic wedge angle reduction, the operation time is longer. There is no significant difference between the two groups in the cement leakage. High-quality randomized trials are needed to confirm these.

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