Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (43): 8038-8041.doi: 10.3969/j.issn.1673-8225.2011.43.015

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Application of artificial total knee prosthesis replacement in limb salvage surgery for osteosarcoma with pathological fracture located in the distal femur

Liu Yi, Cui Zhi-ming, Cui Sheng-yu, Yang Jian, Yan Jian-jun   

  1. Department of Orthopedics, Nantong First People’s Hospital, Nantong  226001, Jiangsu Province, China
  • Received:2011-04-17 Revised:2011-08-11 Online:2011-10-22 Published:2011-10-22
  • Contact: Yan Jian-jun, Chief physician, Department of Orthopedics, Nantong First People’s Hospital, Nantong 226001, Jiangsu Province, China yanjianjun2011@yahoo.com.cn
  • About author:Liu Yi★, Master, Physician, Department of Orthopedics, Nantong First People’s Hospital, Nantong 226001, Jiangsu Province, China liuy2003_1984@yahoo.cn

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Abstract:

BACKGROUND: Amputation surgery as a traditional treatment for osteosarcoma is preferred. With the continuous improvement of chemotherapy, prosthesis manufacturing process and materials science advances, it is possible to keep body functions
OBJECTIVE: To evaluate the effect of artificial total knee prosthesis replacement in the treatment of patients with osteosarcoma and pathological fracture located in the distal femur.
METHODS: Limb salvage surgery with prosthetic knee replacement was performed in 9 patients with osteosarcoma and pathological fracture in the distal femur. The reconstruction of limb function was done using total knee replacement with individualized prosthesis. Neoadjuvant chemotherapy was used in all the cases pre- and postoperatively.
RESULTS AND CONCLUSION: The nine patients were followed up for 6-72 months. Eight cases survived without tumor in 3 years and 6 in 5 years. The 5 years survive rate was 66.7%. The range of extension and flexion of the knee was 0°-100° in 6 cases, and 3 in 0°-70°. The function of the knee was assessed by Enneking system. The results were graded as excellent in 6 patients, good in 2 cases, and fair in 1 case. Material-related inflammation and rejection reactions were not found. It is effective for the treatment of osteosarcoma and pathological fracture in the distal femur through extensive or radical resection and reconstruction by using prosthetic knee replacement.

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