Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (34): 6292-6295.doi: 10.3969/j.issn.1673-8225.2011.34.006

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Electrical stability of fluorine doped tin oxide films carrier materials of electrochemical DNA biochip in different media solutions

Zhang Yu-qin, Wu Hui-jun, Jiang Ye-hua, Zhou Rong   

  1. School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming  650093, Yunnan Province, China
  • Received:2011-02-06 Revised:2011-03-31 Online:2011-08-20 Published:2011-08-20
  • About author:Zhang Yu-qin☆, Doctor, Professor, School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, Yunnan Province, China zyqkust@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 50902063*; Applied Basic Research Program of Yunnan Province, No. 2007E191M*; Science Research Fund of Yunnan Educational Bureau, No. 08J0011*

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Abstract:

BACKGROUND: In electrochemical gene chip, chemical modification of the fluorine doped tin oxide (FTO) films carrier materials and DNA hybridization reactions need to carry on the different media solutions. The corrosion of various media would have a greater influence on characteristics of the carrier materials, and may be cause degradation or failure phenomenon of the carrier materials.
OBJECTIVE: To observe the electrical stability of the FTO films carrier materials in NaOH, NaCl, Na2SO4 media solutions.
METHODS: The electrical stability of the FTO films carrier materials of electrochemical DNA biochip was investigated using the relative resistance change (ΔR/R) method in 1 mol/L NaOH, NaCl, Na2SO4 media solutions at 25 ℃ and 50 ℃.
RESULTS AND CONCLUSION: In the three media solutions, the ΔR/R values of FTO films had a minimal change in NaCl and Na2SO4 media solutions at 25 ℃, while The ΔR/R values in NaOH media solutions at 25 ℃ were much larger than the first two; The ΔR/R values of FTO films showed the same change trends in NaOH, NaCl, Na2SO4 media solutions at 50 ℃. With increasing immersion time, the electrical stability of the films decreased rapidly, and the conductivity of the films decreased. The electrical stability of the FTO films in three media solutions decreased as NaCl, Na2SO4, and NaOH solutions in sequence.

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