Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (23): 4367-4370.doi: 10.3969/j.issn.1673-8225.2010.23.042

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Stem cells in optic nerve protection and restoration following injury

Zhang Min, Huang Bing   

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou   510060, Guangdong Province, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Huang Bing, Master, Associate investigator, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China huangbing2000@ hotmail.com
  • About author:Zhang Min, Studying for master’s degree, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China zhangm35@mail2. sysu.edu.cn
  • Supported by:

    Science and Technology Plan Project of Guangdong Province, No. 2008A060202008*

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Abstract:

BACKGROUND: As a specially differentiated central nerve, optic nerve is once injured, retinal neurons are hard to restore and regenerate. As a result, visual function is lost permanently. Currently, an effective clinical treatment is not available. Due to the multi-directional differentiated potential of stem cells, their role in optic nerve protection and restoration following injury is becoming a hot research spot.
OBJECTIVE: To review the classification and transplantation of stem cells in optic nerve protection study, as well as roles of stem cells transplantation in optic nerve protection and repair following injury.
METHODS: The database of ISI Web of Knowledge platform was searched on computer from February 1994 to April 2009, with the key words “stem cells, optic nerve” in English. In the same way, the database of CNKI from February 1994 to April 2009 was also screened, with the key words “stem cells, optic nerve” in Chinese.
RESULTS AND CONCLUSION: A total of 98 literatures related to stem cells in optic nerve protection and restoration after injury are collected, in which 23 papers are Chinese and 75 papers are English. The studies published earlier, repetitively and similarly are removed, and 38 papers which comply with the standards are involved into this review. Stem cells own the potential of self-renew physiologically, as well as potential of repairing the injuries. At present, most of the researches on stem cells in optic nerve protection and restoration after injury are represented in morphosis. How to implant stem cells safely and effectively and how to recover stable visual function still need our efforts. Stem cells derived from skin, peripheral blood, fat and other tissues are convenient to draw materials and are commendable subjects, we should study them deeply to make preferable use.

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