Compatibility of osteoblasts with shape memory polyurethane before and after the deformation-complex

doi:10.3969/j.issn.2095-4344.2015.52.016

Abstract

Abstract:

BACKGROUND: Shape memory polyurethane has good physical and chemical properties and compatibility, but there are relatively few reports on the compatibility of osteoblasts before and after the deformation-complex of the shape memory polyurethane.

OBJECTIVE: To observe the compatibility of osteoblasts with shape memory polyurethane before and after the deformation-complex.

METHODS: Shape memory polyurethane membranes were prepared, and its stretching-solid-complex was conducted under the experimental environment, to obtain the membrane materials after the deformation-complex. The Sprague-Dawley neonatal rat osteoblasts were inoculated on the shape memory polyurethane membranes before and after the deformation-complex. After 2 hours of culture, the number of adherent cells was counted, and cell spreading was observed; cell proliferation was determined after 1-11 days of culture.

RESULTS AND CONCLUSION: The adhesion amount and proliferation activity of osteoblasts on shape memory polyurethane membranes after the deformation-complex were significantly higher than those before the deformation-complex (P < 0.05). The osteoblasts presented fusiform appearance on the shape memory polyurethane membranes after deformation-complex, and cell arrangement showed a clear orientation, but a small spreading area; while the osteoblasts presented polygonal shape on the shape memory polyurethane membranes before deformation-complex, arranged in no particular direction, and spread largely. These findings show the shape memory polyurethane has better osteoblast compatibility after the deformation-complex.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

CLC Number:

R318

Ye Mao, Luo Meng, Zou Yi, Leng Hua-wei, Zhang Jun-quan. Compatibility of osteoblasts with shape memory polyurethane before and after the deformation-complex[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(52): 8450-8454.

Figures/Tables 4

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