Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (49): 8005-8009.doi: 10.3969/j.issn.2095-4344.2015.49.023

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Evaluation of Xiaozhiling injection effect on rectal internal mucosal prolapse based on the amount of displacement of mucosal nodes in a finite element model of rabbit anorectum

Ke Min-hui1, Ye Ling1, Chen Li-wu1, Niu Su-sheng2, Zheng Ming-xiao1, Zhang Zhi-xi3   

  1. 1Department of Anorectal Surgery, Second People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China; 2College of Osteopathy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China; 3Laboratory of Photoelasticity, Fuzhou University, Fuzhou 350108, Fujian Province, China
  • Received:2015-09-06 Online:2015-11-30 Published:2015-11-30
  • Contact: Ye Ling, Chief physician, Department of Anorectal Surgery, Second People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China
  • About author:Ke Min-hui, Master, Attending physician, Department of Anorectal Surgery, Second People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81173272; the Natural Foundation of Fujian Province of China, No. 2015J01402

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Abstract:

BACKGROUND: Previous studies have confirmed a scheme of establishing rabbit models of rectal internal mucosal prolapse within 2 months, which were similar to rectal internal mucosal prolapse in humans and had good stability. At present, Xiaozhiling injection is a preferred traditional Chinese medicine for treatment of rectal internal mucosal prolapse. Its short-term curative effect is positive, but rectal internal mucosal prolapse recurs after long-term administration of Xiaozhiling injection.
OBJECTIVE: To evaluate the effect of Xiaozhiling injection in the treatment of rectal internal mucosal prolapse based on the amount of displacement of mucosal nodes in a finite element model of rabbit anorectum.
METHODS: Thirty-two rabbit models of rectal internal mucosal prolapse were randomly divided into rectal internal mucosal prolapse group (n=8) and Xiaozhiling injection group (n=24). Rbbits in the rectal internal mucosal prolapse group were sacrificed and dissected to harvest the rectum for mechanical measurements. At the 3rd, 7th and 14th days after administration of Xiaozhiling injection, eight rabbits per time point from the Xiaozhiling 
injection group were sacrificed to harvest the rectum for mechanical measurements. At last, the data from these two groups were input into a finite element model of the rabbit anorectum. The nodes in different coronal planes (ventral, middle and dorsal) were selected on three rectal mucosal cross-sections harvested from different areas (above, at and below the anorectal angle). The amounts of displacement of these nodes were measured under the condition of simulated defecation.
RESULTS AND CONCLUSION: There was significant difference in the amount of displacement of each node between different time periods before and after administration of Xiaozhiling injection. There was significant difference in the amount of displacement between mucosal nodes from the same cross-section and between mucosal nodes from the same coronal plane in the same time period before and after administration of Xiaozhiling injection. These results suggest that Xiaozhiling injection is effective in the treatment of rectal internal mucosal prolapse, however, the difference in amount of displacement of different nodes in the rectal mucosa finite element after administration of Xiaozhiling injection may be one of the factors affecting the efficacy.  

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