Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (38): 6205-6210.doi: 10.3969/j.issn.2095-4344.2015.38.025

Previous Articles     Next Articles

The development of an in vitro loading device for vascular tensile stress

Lei Ya-nan1, Ding Hao1, 2, Lan Hai-lian1, Yang Qian1, Liu Zhi-lin3   

  1. 1School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 
    2Shanghai University of Medicine & Health Sciences, Shanghai 200093, China; 3Shanghai General Hospital, Shanghai 200080, China
  • Contact: Ding Hao, M.D., Professor, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Shanghai University of Medicine & Health Sciences, Shanghai 200093, China
  • About author:Lei Ya-nan, Studying for master’s degree, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
  • Supported by:

    the Scientific Research Innovation Project of Shanghai Municipal Education Committee, No. 13YZ148

PDF

206

Abstract:

BACKGROUND: After years of development, various in vitro loading devices for vascular tension stress have been created both at home and abroad, mainly including rectangular base stretching method, circular base deformation method and four-point bending beam load method. Although the circular base deformation method can well reflect the real situations in vivo such as the expansion of the alveoli and vascular pulsation, the strain on the membrane is actinomorphic. The four-point bending beam load method can just bring limited strain range and load time, along with a difficult strain regulation.
OBJECTIVE: To develop an in vitro loading device for vascular tension stress using the rectangular base stretching method. 
METHODS: This in vitro loading device for vascular tension stress developed according to mechatronics design consisted of power supply module, control module, drive module and data acquisition module. The device could 
achieve the tensile control on silicon diaphragm by high-precision control of the motor rotation angle and rotational speed.
RESULTS AND CONCLUSION: Through tests and experiments, the device could meet the required range of parameters and simulate in vitro human tensile stress environment, which is preliminarily considered to develop successfully, achieving that: (1) two work patterns: stress mode and strain mode so as to solve the standardization of silicone substrate as loading device; (2) tensile stress can be adjusted in a range of 0-5×105 Pa; (3) tensile strain can be adjusted in 0-40% range; (4) stretching frequency can be in the regulation of 0-80 times/min and the stretching time can be controlled.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Cardiovascular diseases, Silica Gel

CLC Number: