Vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries

doi:10.3969/j.issn.2095-4344.2015.34.017

Abstract

Abstract:

BACKGROUND: Vascular grafts made of expanded polytetrafluoroethylene have been shown to have highly hydrophobic surface characterized by resistance to water penetration and biological durability.

OBJECTIVE: To investigate the effects of vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries.

METHODS: Thirty-eight patients with peripheral arterial injuries, consisting of 30 males and 8 females, aged 17-61 years, were included in this study. After conventional fluid infusion, anti-shock treatment, anti-inflammation, and debridement, they received implantation of vascular grafts made of expanded polytetrafluoroethylene. A 12-month follow-up observation was performed to investigate the recovery of affected limbs and vascular patency in patients.

RESULTS AND CONCLUSION: After implantation of vascular grafts made of expanded polytetrafluoroethylene, all vessels were unblocked and no cases died or had limbs amputated. Blood supply of all affected limbs recovered to normal and there was no vascular anastomotic infection. Imaging results showed that vascular patency rate was 100%. Ultrasound examination results showed that at the end of the follow-up period, the inner wall of the vascular grafts was smooth, obvious mural thrombus or anastomotic stenosis did not occur in any case, vascular patency rate was 92% (35/38), and no adverse reactions related to artificial vessels were observed. These findings suggest that vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries exhibit striking surface anticoagulant property and long-term patency.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Biocompatible Materials;, Polytetrafluoroethylene, Blood Vessel Prosthesis

CLC Number:

R318

Zhang Han-jiang, Wang Zhi-wei . Vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(34): 5496-5500.

Figures/Tables 1

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