MRI tracing of stem cells: theory and application progress

doi:10.3969/j.issn.2095-4344.2015.28.029

Abstract

Abstract:

BACKGROUND: Continuous monitoring is required in the survival, distribution, migration, proliferation and differentiation of transplanted stem cells in vivo thereby to assess its efficacy and safety.
OBJECTIVE: To analyze the characteristics of literature addressing stem cell markers and MRI tracer in the past 10 years.
METHODS: The first author retrieved CNKI and Web of Science by computer for articles about MRI tracing of stem cells published from January 2005 to December 2014, using the keywords of “stem cells, magnetic resonance imaging, tracing technique” that appeared in the title and abstract. Then, the retrieved articles were further analyzed.
RESULTS AND CONCLUSION: Currently, tracing technique has been widely used in stem cell therapy, organ transplantation, bacterial infection, gene expression and new drug development. Stem cell tracing technologies include isotope tracing, antigenic labeling, fluorescence protein labeling, fluorescent dye labeling, nuclear magnetic resonance contrast enhancer labeling, Lac-Z gene labeling, Y chromosome labeling. Recently, with the development of molecular imaging, MRI tracing techniques have been increasingly used to assess the efficacy and safety of stem cell transplantation.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem Cell Transplantation, Magnetic Resonance Imaging, Mesenchymal Stem Cell Transplantation

CLC Number:

R318

Long Teng-he, Cui Hui-qin. MRI tracing of stem cells: theory and application progress[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(28): 4588-4592.

Figures/Tables 2

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