Changes in serum C-reactive protein level and erythrocyte sedimentation rate in patients after use of orthopedic metal implants

doi:10.3969/j.issn.2095-4344.2015.25.007

Abstract

Abstract:

BACKGROUND: Most orthopedic surgeries use metal implants. Although this approach will benefit for patients, it simultaneously makes patients infected by some bacteria. Serum C-reactive protein level and erythrocyte sedimentation rate are two indices for clinically determining the inflammation.
OBJECTIVE: To investigate the changes in serum C-reactive protein level and erythrocyte sedimentation rate in patients after use of orthopedic metal implants.
METHODS: The clinical data of 100 patients who used metal implants between October 2012 and October 2014 at the Department of Orthopedics, Linqu People’s Hospital of Shandong Province of China were retrospectively analyzed. Among these patients, 36 patients received implantation of intramedullary nails, 34 patients artificial joint, and 30 patients steel plates. At 1, 3, 7, 14, and 21 days after implantation, infection was determined according to serum C-reactive protein level and erythrocyte sedimentation rate, as well as other laboratory indices, wound healing, and body temperature. According to these indices, the patients were assigned to two
groups: no infection (n=52) and infection (n=48). Disease progression was analyzed for providing reliable evidence for rational use of antibiotics.
RESULTS AND CONCLUSION: There were significant differences in serum C-reactive protein level and erythrocyte sedimentation rate in patients between infection and non-infection groups at 1 (t=3.43, P < 0.05; t=3.78, P < 0.05), 3 (t= 3.35, P < 0.05; t=3.68, P < 0.05), 7 (t=3.28, P < 0.05; t=3.54, P < 0.05), and 14 days after use of orthopedic metal implants (t=2.56, P < 0.05; t=3.02, P < 0.05). No significant differences in these two indices were observed between infection and non-infection groups at 21 days after use of orthopedic metal implants (t=1.76, P > 0.05; t=1.98, P > 0.05). These findings suggest that after use of orthopedic metal implants, serum C-reactive protein level and erythrocyte sedimentation rate in patients should be closely monitored and simultaneously other indices like wound healing and body temperature should be determined to determine whether infection occurs after use of orthopedic metal implants so as to develop effective repair strategies. This will provide reliable clinical evidence for rational treatment and prevention of orthopedics-related diseases.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Internal Fixators, Prosthesis Implantation, C-Reactive Protein, Blood Sedimentation

CLC Number:

R318

Li Guo-dong. Changes in serum C-reactive protein level and erythrocyte sedimentation rate in patients after use of orthopedic metal implants[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(25): 3967-3971.

Figures/Tables 3

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