Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (18): 2891-2895.doi: 10.3969/j.issn.2095-4344.2015.18.018

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Histopathology changes and transforming growth factor-bata1 expression in the ligamentum flavum of C4/5 cervical instability animal models

Bu Xian-min1, Wu Bin2, Xu Fang-fang1, Meng Chun-yang2, Wang Hai-bin2   

  1. 1Department of Pathology, First People’s Hospital of Jining, Jining 272000, Shandong Province, China; 2Department of Orthopedics, Affiliated Hospital of Jining Medical College, Jining 272000, Shandong Province, China
  • Received:2015-03-30 Online:2015-04-30 Published:2015-04-30
  • About author:Bu Xian-min, Master, Attending physician, Department of Pathology, First People’s Hospital of Jining, Jining 272000, Shandong Province, China
  • Supported by:

    the Youth Foundation of Jining Medical College, No. 20090511; the Natural Science Foundation of Shandong Province of China, No. ZR2014CQ042

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Abstract:

BACKGROUND: Destroying posterior stable structure of cervical vertebra may facilitate the ligamentum flavum regeneration. Whether anterior cervical instability can induce the regeneration in posterior and adjacent ligamentum flavum remains unclear.
OBJECTIVE: To observe the changes of transforming growth factor-β1 expression and histopathology in the ligamentum flavum of cervical instability animal models. METHODS: Thirty-six New Zealand white rabbits were randomly divided into control group and experimental group, with 18 rabbits in each group. In the experimental group, cervical instability animal models were established made through destroying annulus fibrosus by anterior puncture and absorbing nucleus pulposus in C4/5. And no intervention was given to the control group.
RESULTS AND CONCLUSION: Compared with the control group, fibers in the C3/4, 4/5, 5/6 ligamentum flavum arranged disorderly and the glass like degeneration was found in the experimental group. The expression of transforming growth factor-β1 in ligamentum flavum was increased, especially in C4/5, in the experimental group. At 4, 8, 12 weeks, transforming growth factor-β1 expression in the C3/4, 4/5, 5/6 ligamentum flavum segments was similar between the two groups. Experimental findings indicate that, anterior cervical instability can induce the regeneration in posterior ligamentum flavum, especially in the injured segment.



中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程


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Key words: Transforming Growth Factor-β1, Cervical Vertebrae, Ligamentum Flavum, Intervertebral Disk Degeneration

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