Intramedullary nailing support combined with tissue-engineered bone filling for treating fibrous dysplasia of the proximal femur

doi:10.3969/j.issn.2095-4344.2014.04.017

Abstract

Abstract:

BACKGROUND: Tissue-engineered bone in the treatment of large bone defects has obvious advantages especially when the autologous ilium transplantation is limited, which can effectively fill bone defects.

OBJECTIVE: To investigate the rationality of intramedullary nailing support and tissue-engineered bone filling in the treatment of fibrous dysplasia of the proximal femur and the biocompatibility of the tissue-engineered bone.

METHODS: Seven patients with fibrous dysplasia of the proximal femur were subjected to intramedullary nailing support and tissue-engineered bone filling.

RESULTS AND CONCLUSION: All of the seven patients underwent more than 8 months of follow-up, no rejection reaction and other complications occurred. After 4-6 weeks of fixation, all the seven patients removed hip spica braces, with a good hip mobility. After 10-12 weeks, X-ray review showed no pathological fracture, internal fixation loosening and narrow neck stem angle. Using the Harris hip score evaluation of the hip function, the affected side of the seven patients was optimized. After 16-18 weeks, X-ray films reviewed good creeping substitution in the affected area treated with the intramedullary nailing support and bone graft. After 24-26 weeks, new bone appeared within the scope of lesions. After 1.0-1.5 years, bone creeping substitution was basically completed in the intertrochanteric region, and original lesions were invisible on X-ray films. These findings confirmed that intramedullary nailing support and tissue-engineered bone filling for treating fibrous dysplasia of the proximal femur has good effectiveness, exhibiting stable internal fixation and avoiding resection of autogenous iliac bone. Tissue-engineered bone has a good biocompatibility in the medium-term follow-up, with good hip function activities.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

全文链接：

Key words: bone transplantation, fracture healing, ilium, femoral fractures, fracture fixation

CLC Number:

R318

Chen Peng, Wu Xue-jian, Zhu Xu, Xiao Peng. Intramedullary nailing support combined with tissue-engineered bone filling for treating fibrous dysplasia of the proximal femur[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(4): 589-594.

Figures/Tables 2

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