Abstract:

BACKGROUND: Osteoprotegerin-receptor activator of nuclear factor-κB ligand-receptor activator of nuclear factor-κB (OPG/RANKL/RANK) signal pathway is a classic signaling pathway for bone metabolism. Interleukin-6 (IL-6) has a correlation with the OPG/RANKL/RANK signal pathway. The effect of exercise on bone metabolism is highly related with the modulation of the two above.
OBJECTIVE: To research the modulation of OPG/RANKL/RANK signal pathway on bone metabolism under the inducement of IL-6 at moving state and to find the inherent relationship between IL-6 and OPG/RANKL/RANK signal pathway.
METHODS: CNKI, EBSCO and Elsevier databases were retrieved by computer for papers concerning exercise stress, IL-6, and OPG/RANKL/RANK . Thirty-nine representative and updated papers were chosen and analyzed to reveal the relationship among exercise, IL-6 and OPG/RANKL/RANK signal pathway.
RESULTS AND CONCLUSION: These analyses suggested that there is high correlation between IL-6 and OPG/RANKL/RANK in the process of bone metabolism. The expressions of IL-6 and OPG/RANKL/RANK signal pathway at different exercise intension and load have specific exercise stress response and adaption .These osteoarthrosis findings could not only help to reveal the mechanism of exercise for bone health, but also be applied to prevent and treat osteoarthrosis.