Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (37): 6998-7002.doi: 10.3969/j.issn.2095-4344.2012.37.031

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An animal model of maxillofacial distraction osteogenesis

Huang Xuan-ping, Jiang Xian-fang, Zhou Nuo   

  1. Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-11-14 Revised:2011-12-30 Online:2012-09-09 Published:2012-09-09
  • Contact: Zhou Nuo, Professor, Doctoral supervisor, Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China nuozhou@hotmail.com
  • About author:Huang Xuan-ping☆, Doctor, Associate professor, Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China hxp120@126.com

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Abstract:

BACKGROUND: The animal model establishment is an important part for the research of maxillofacial distraction osteogenesis.
OBJECTIVE: To review the research process of the establishment of maxillofacial distraction osteogenesis animal model.
METHODS: All the literatures were searched in the PubMed database, SCI database, VIP database and Wanfang database (2000/2001) with the key words of “distraction osteogenesis, mandibular, maxillary, craniofacial” in English or Chinese. A total of 28 articles were collected and analyzed in the aspects of the establishment of maxillofacial distraction osteogenesis animal model, and experimental animal selection and application.
RESULTS AND CONCLUSION: The animals selected for the experiment should be similar to human in the aspects of structure, function, metabolism and disease characteristics. Standardized, anatomical and physiological characteristics animals that consistent with the requirements of experimental purposes were selected. The growth characteristics of the selected animals and research purposes in the process of distraction osteogenesis, as well as the stretch-rate and fixed term in the intermission of distraction should be considered.

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