Chinese Journal of Tissue Engineering Research ›› 2018, Vol. 22 ›› Issue (3): 356-361.doi: 10.3969/j.issn.2095-4344.0030
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Hu Wen-hao
Online:
2018-01-28
Published:
2018-01-28
About author:
Hu Wen-hao, Master, Department of Orthopedics, the Affiliated Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, Jiangsu Province, China
Supported by:
the Project of Nanjing Medical University, No. 2016NJMU142
CLC Number:
Hu Wen-hao. Efficacy of intravenous versus topical administration of tranexanmic acid in primary total knee arthroplasty[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(3): 356-361.
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2.2 失血量对比 通过对比发现,静脉应用氨甲环酸组、局部应用氨甲环酸组与对照组相比,应用氨甲环酸2组的术中失血量及术后引流量有明显降低,通过引流管在关节腔内局部应用氨甲环酸,术后引流量减少了约189.8 mL;静脉应用氨甲环酸组的术后引流量减少了约154.4 mL,差异有显著性意义(P < 0.05)。在2个应用氨甲环酸组中,局部应用氨甲环酸相对于静脉应用,术后引流量可以减少 35.4 mL,差异有显著性意义(P < 0.05);而静脉应用氨甲环酸组的总失血量(术中失血量+术后引流量)低于局部应用氨甲环酸组,差异有显著性意义(P < 0.05),见图2,3。 2.3 血红蛋白水平对比 与术前血红蛋白水平相比,静脉应用氨甲环酸组、局部应用氨甲环酸组与对照组的术后血红蛋白分别下降(19.2±9.6)g/L,(26.7±10.5)g/L,(34.4± 10.4)g/L。在2个应用氨甲环酸组中,血红蛋白的下降水平均明显低于对照组(P < 0.05);静脉应用氨甲环酸组血红蛋白的下降水平明显低于局部应用氨甲环酸组(P < 0.05),见图4。 2.4 术后并发症 各组患者术后伤口及关节无明显红肿,14 d拆线时手术切口愈合良好。术后所有患者出院前膝关节功能达到伸直0°,屈曲≥90°。术后第14天行双下肢动静脉血管B超检查,均未发现静脉血栓形成。所有患者均未出现肺栓塞表现,未行胸部CT扫描。 "
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