Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (20): 3671-3674.doi: 10.3969/j.issn.1673-8225.2012.20.014

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Formation of glial scar in the rat spinal cord after injury

Huang Kai, Sheng Wei-bin   

  1. Department of Spinal Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China
  • Received:2012-02-10 Revised:2012-04-19 Online:2012-05-13 Published:2012-05-13
  • Contact: Sheng Wei-bin, Doctor, Professor, Chief physician, Doctoral supervisor, Department of Spinal Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China wbsheng_xjmu@hotmail.com
  • About author:Huang Kai★, Studying for master’s degree, Physician, Department of Spinal Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China 34556746@qq.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81060106*

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Abstract:

BACKGROUND: After spinal cord injury, the treatment cannot completely solve the problem with the body because glial scar forms and cystic degeneration occurs in the spinal cord tissue. Therefore, it is of great significance to know the regularity of glial scar development.
OBJECTIVE: To analyze the spatial distribution, characteristics of axon and time characteristics of glial scar in the rat spinal cord after experimental spinal cord injury.
METHODS: SD rats were divided into control group, 1-day group, 3-day group, 5-day group, 1-week group, 2-week group, 4-week group, 6-week group, 8-week group, 10-week group and 12-week group. Allen’s weight-drop method was performed to prepare spinal cord injury models in rats expect the control group.
RESULTS AND CONCLUSION: At 4 weeks after spinal cord injury, glial scar and smooth cavity wall began to form. No astrocytes positive for glial fibrillary acidic protein and axons positive for neurofilament protein existed inside the cavity. The glial scar begun to stabilize at 4 weeks after spinal cord injury, and mechanical barriers between the cavity and axon came into being. Thickness of the glial scar no more increased at 10 weeks after spinal cord injury.

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