Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (11): 2047-2050.doi: 10.3969/j.issn.1673-8225.2012.11.034

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Stress stimulation and signal pathways of osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand in bone metabolism 

Wang Dan, Bao Jie, Wang Guo-xiang   

  1. Department of Physical Education, Soochow University, Suzhou  215021, Jiangsu Province, China
  • Received:2011-09-07 Revised:2011-12-14 Online:2012-03-11 Published:2012-03-11
  • Contact: author: Wang Guo-xiang, Doctor, Professor, Doctoral supervisor, Department of Physical Education, Soochow University, Suzhou 215021, Jiangsu Province, China kwang63@163.com
  • About author:Wang Dan★, Studying for master’s degree, Department of Physical Education, Soochow University, Suzhou 215021, Jiangsu Province, China wangdan6953@126.com
  • Supported by:

    the Jiangsu Provincial Innovative Research Program for Postgraduates in Regular Institutions of Higher Learning in 2011, No. CXZZ11_0069*; the Key Program of Natural Science Foundation of Jiangsu Province for Provincial Colleges and Universities, No. 11KJD320001*

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Abstract:

 

BACKGROUND: Signal pathway of osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand in bone metabolism is one of the accesses to cope with the stress sensitivity. Different types of the exercise can produce different types of stress stimulation, and influence the signal pathways in bone metabolism.
OBJECTIVE: To explore the influence of different types of exercise on the signal pathways of osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand in bone metabolism.
METHODS: An online search of CNKI, HighWire and Elsevier databases was performed for articles related to “stress stimulation, osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand”. Articles published from 2000 to 2011 with the keywords of “stress stimulation, osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand” or “stress stimulation, bone metabolism” were included. Articles related to the effects of stress stimulation on the signaling pathways were selected. Articles published recently or in the authorized journals were of priority. A total of 215 articles were collected in the initial research, and 31 of them were retained according to inclusion and exclusion criteria.
RESULTS AND CONCLUSION: Exercise continuously produces stress stimulation on bone. This mechanical stress stimulation regulates the bone tissue metabolism by affecting the signal regulating system of osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand. But the results in relevant articles are inconsistent. Therefore further study is needed.
 

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