Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (11): 2039-2042.doi: 10.3969/j.issn.1673-8225.2012.11.032

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Application of bone morphogenetic proteins in mandibular fast distraction osteogenesis

Liu Hao, Wang Min   

  1. Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-09-17 Revised:2011-09-27 Online:2012-03-11 Published:2012-03-11
  • Contact: author: Wang Min, Doctor, Professor, Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China hxkqwangm@163.com
  • About author:Liu Hao★, Studying for master’s degree, Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China liuhaofrank@163.com
  • Supported by:

    Public Project of Science and Technology Agency of Sichuan Province, No. 2008FN0174*

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Abstract:

BACKGROUND: Distraction osteogenesis has became an effective method in treatment of different kinds of craniofacial deformities and bone defects. However, the major disadvantage of this method is the long distraction and consolidation period, which may lead to severe complications during the distraction process.
OBJECTIVE: To summarize the research progress of the application of bone morphogenetic proteins (BMPs) in fast distraction osteogenesis.
METHODS: A computer-based online search in Pubmed database was performed to select the reviews and papers related to BMPs and distraction osteogenesis from 1989 to 2011.
RESULTS AND CONCLUSION: A total of 32 literatures on the the application of BMPs in fast distraction osteogenesis were included. BMPs have a strong osteogenic activity and capability of promoting regeneration and remodeling of bone. The present research shows that BMPs can be used to accelerate new bone formation and shorten the treatment period. However, the clinical application of BMPs needs further research.

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