Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (5): 885-894.doi: 10.3969/j.issn.1673-8225.2012.05.030

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Immunosuppressant medicines for renal transplantation: A literature analysis based on Science Citation Index database from 2001 to 2010  

Guo Yi-tong1, Tan Zhi-gang2   

  1. 1Department of Internal Medicine, Ninth People's Hospital of Shenyang, Shenyang  110024, Liaoning Province, China; 2Department of Emergency, Fengtian Hospital Affiliated to Shenyang Medical College, Shenyang  110024, Liaoning Province, China
  • Received:2011-11-18 Revised:2011-12-08 Online:2012-01-29 Published:2012-01-29
  • Contact: Tan Zhi-gang, Master, Chief physician, Associate professor, Department of Emergency, Fengtian Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China zhigangtan@ sohu.com
  • About author:Guo Yi-tong★, Master, Associate chief physician, Department of Internal Medicine, Ninth People's Hospital of Shenyang, Shenyang 110024, Liaoning Province, China 908176705@ qq.com

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Abstract:

BACKGROUND: Immunosuppressive medication plays an important role in renal transplantation. The use of immunosuppressant medicine for renal transplantation will affect survival of humans/kidneys after kidney transplantation as well as patient’s quality of life.
OBJECTIVE: The literature regarding various immunosuppressant medicines for renal transplantation in Science Citation Index (SCI) database was analyzed to understand the trends of studies on immunosuppressant medicine for renal transplantation.
DESIGN: Bibliometric analysis.
DATA RETRIEVAL: A retrieval was performed for the literature of various immunosuppressant medicines for renal transplantation, including azathioprine/ Aza, cyclosporin A/CsA, rapamycin/sirolimus, mycophenolate mofetil and tacrolimus/FK506 during 2001-01 and 2010-12 in SCI. Quantitative analysis was used to analyze the literatures based on their document type, publication time, country, funding agency, citation, and author.
SELECTIVE CRITERIA: Articles on immunosuppressant medicine for renal transplantation including the following types: (1) Peer-reviewed original paper; (2)Reviews; (3)Meeting notes and abstracts; (4)Letters; (5)Editorial materials. Exclusive criteria were included (1)Articles unrelated the study of immunosuppressant medicine for renal transplantation; (2)Articles published before 2001; (3)Articles which were not published on journals; (4)Articles which need to be retrieved by phone or manually.
MAIN OUTCOME MEASUREMENTS: (1)Document type distribution. (2)Publication time distribution. (3)Country distribution.
(4)Funding agency distribution. (5)Journal distribution. (6)Citation frequency. (7)Author output. (8)Comparison of literature  regarding five immunosuppressants for renal transplantation.
RESULTS: (1)6 224 papers on immunosuppressant medicine for renal transplantation were retrieved in SCI database, in which most of paper were published as original articles. Twenty-two articles were identified as classic literature. (2)The overall number of literature had an upward trend from 2001 to 2005, and a downward trend from 2006 to 2010. (3)Forty-nine papers were funded by National Institutes of Health (NIH). (4)Transplantation Proceedings published most papers in this field (914), followed by Transplantation (777) and American Journal of Transplantation (535). Transplantation Proceedings was recognized as the core journal in the area.
CONCLUSION: The analysis of international literature shows the development of immunosuppressant medicine for renal transplantation, which could provide reference for subject experts to further study unsolved issues in the field.

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