Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (52): 9696-9700.doi: 10.3969/j.issn.1673-8225.2011.52.002

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Effect of Uygur medicine Maizhuni on the expression of matrix metalloproteinase 1 and tissue inhibitor of matrix metalloproteinase 1 in the articular cartilage of rat osteoarthritis models

Zhang Yao-wu1, Fang Rui2, Liu Zhen-feng2, Ailijiang•Asila2, Meng Qing-cai2   

  1. 1Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China
    2Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region, Urumqi  830000, Xinjiang Uygur Autonomous Region, China
  • Received:2011-10-13 Revised:2011-11-02 Online:2011-12-24 Published:2011-12-24
  • Contact: Meng Qing-cai, Doctor, Chief physician, Doctoral supervisor, Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, Xinjiang Uygur Autonomous Region, China mengqingcai@medmail.com.cn
  • About author:Zhang Yao-wu★, Studying for master’s degree, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China yaowuz@yahoo.cn
  • Supported by:

    the Key Technology Research and Development Program of Xinjiang Uygur Autonomous Region, No. 200933126*

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Abstract:

BACKGROUND: Articular cartilage damage in osteoarthritis patients is related to the imbalance between matrix metalloproteinase 1 and tissue inhibitors of matrix metalloproteinase.
OBJECTIVE: To investigate the expression of matrix metalloproteinase 1 and tissue inhibitor of matrix metalloproteinase 1 in articular cartilage and the intervention effects of Uygur medicine Maizhuni.
METHODS: Knee osteoarthritis model was constructed using modified Hulth method. A total of 20 healthy SD rats were randomly divided into Maizhuni group and model group. Rats were treated with Uygur medicine Maizhuni or saline by gavage in the 2nd week after model construction for 4 weeks.
RESULTS AND CONCLUSION: Compared with model group, the degree of rat knee joint cartilage degeneration in Maizhuni group was alleviated. The cartilage general score and Mankin score in Maizhuni group was lower than that in the model group (P < 0.05). The expression of matrix metalloproteinase 1 in knee joint chondrocytes of Maizhuni group decreased than that of the control group (P < 0.05); the expression of tissue inhibitor of matrix metalloproteinase 1 in Maizhuni group increased than that in the model group (P < 0.05). These findings indicate that Uyghur medicine Maizhuni may protect articular cartilage by down-regulating the expression of matrix metalloproteinase 1 and up-regulating the expression of tissue inhibitor of matrix metalloproteinase 1.

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