Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (46): 8737-8740.doi: 10.3969/j.issn.1673-8225.2011.46.045

Previous Articles    

Association between A163G polymorphism of the osteoprotegerin gene and bone mineral density in the Chinese elderly from Beijing Area

Wei Ya-nan, Liu Jie, Chen Ling-xia, Jia Rong, Miao Yi-de   

  1. Department of Geratology, Peking University People’s Hospital, Beijing 100044, China
  • Received:2011-06-11 Revised:2011-06-21 Online:2011-11-12 Published:2011-11-12
  • About author:Wei Ya-nan★, Master, Attending physician, Department of Geratology, Peking University People’s Hospital, Beijing 100044, China y.n.wei@hotmail.com
  • Supported by:

    Research and Development Foundation of Peking University People’s University, No. RDI2008-02*

PDF

321

Abstract:

BACKGROUND: Osteoprotegerin gene is the candidate gene of osteoporosis, and the ethnic divergence of gene polymorphisms exists. 
OBJECTIVE: To investigate the association between A163G polymorphism of the osteoprotegerin gene and bone mineral density in the elderly in Beijing.
METHODS: A total of 307 elderly were included in this study. The bone mineral density in proximal femur, lumbar vertebra and forearm was determined by dual energy X-ray absorptiometry and DNA was extracted from peripheral blood. The A163G polymorphism of the osteoprotegerin gene was assessed by polymerase chain reaction-restriction fragment length polymorphism analysis and gene sequencing was performed. Differences in bone mineral density among different genotypes were compared using one-way analysis of variance. Bone mineral density-related factors were analyzed using multiple stepwise linear regression analysis. 
RESULTS AND CONCLUSION: In elderly women, the AA genotype of the A163G was associated with significantly lower bone mineral density at lumbar and femoral inter area; while in elderly men, no association was found between the A163G polymorphisms and bone mineral density. These findings suggest that A163G genotypes in the osteoprotegerin gene promoter are associated with bone mineral density in elderly women.

CLC Number: