Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (43): 8089-8092.doi: 10.3969/j.issn.1673-8225.2011.43.027

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Focal target controlling during high intensity focused ultrasound therapy based on respiratory gating

Zhang Jie, Zhao Chun-liang, Tan Jian-wen, Zhong Ling, Wang Hua   

  1. State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, Department of Biomedical Engineering, Chongqing Medical University, Chongqing  400016, China
  • Received:2011-04-12 Revised:2011-09-07 Online:2011-10-22 Published:2011-10-22
  • Contact: Wang Hua, Professor, State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, Department of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China wangh@haifu.com.cn
  • About author:Zhang Jie★, Master, State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, Department of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China zhangj6647@163.com
  • Supported by:

    the National 973 Program of China, No. 2011CB707902*; the National Natural Science Foundation of China, No. 30830040*

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Abstract:

BACKGROUND: It is an urgent problem to be solved that the organ of displacement caused by breathing could affect the precision of the target of orientation and also the safety of the therapy during the routine treatment.
OBJECTIVE: To study the feasibility that using the respiratory gating to improve the accuracy of focal point positioning during high intensity focused ultrasound (HIFU) therapy.
METHODS: HIFU ablation based on breathing gated control using piezoresistive micro-breathing sensor was applied to the rabbit liver in vivo, which was compared with the normal HIFU ablation procesure for the difference in coagulative necrosis produced under the same ultrasound intensity and ablation duration.
RESULTS AND CONCLUSION: The rabbits were executed immediately after HIFU ablation to investigate lesions inside the liver. Results showed that the biological focal region using breathing gated HIFU ablation was 4.5 mm×2 mm at the largest sectional plane, while that using normal HIFU ablation procesure was 9 mm×2.5 mm. The respiratory gating could eliminate the influence of the accuracy of focal point positioning during HIFU therapy.

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