Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7783-7786.doi: 10.3969/j.issn.1673-8225.2011.41.046

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Serum levels of matrix metalloproteinase-3 and osteoprontin during bone metabolism in Chinese postmenopausal women

Zhang Han-qing1, Dai Yi1, Li Hao2, Guo Zhang-qiang3, Yin Tao4, Wang Du5   

  1. 1Department of Orthopedics, Wuhan Hospital of Traditional Chinese Medicine, Wuhan  430014, Hubei Province, China
    2Department of Orthopedics and Trauma, Hubei Hospital of Traditional Chinese Medicine, Wuhan  430060, Hubei Province, China
    3Pu’ai Hospital of Wuhan, Wuhan  430030, Hubei Province, China
    4Union Hospital Affiliated to Huazhong University of Science and Technology, Wuhan   430000, Hubei Province, China
    5Wuhan Third Hospital, Wuhan  430000, Hubei Province, China
  • Received:2011-06-27 Revised:2011-08-19 Online:2011-10-08 Published:2011-10-08
  • Contact: Dai Yi, Doctor, Department of Orthopedics, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430014, Hubei Province, China daiyifreeman@yahoo.com.cn
  • About author:Zhang Han-qing☆, Doctor, Associate chief physician, Department of Orthopedics, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430014, Hubei Province, China zhqwh@yahoo.com.cn
  • Supported by:

    a Project of Youth Talent in Science and Technology of Health Department of Hubei Province, No. QJX2010-48*; Youth Science and Technology Chenguang Development Program of Wuhan, No. 200950431215*; Clinical Medicine Program of Health Department of Wuhan, No. WZ10C02*

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Abstract:

BACKGROUND: Osteopontin (OPN) has a great affinity for matrix metalloproteinase groups-3 (MMP-3). The expression of OPN and MMP-3 may play an important role in bone metabolism.
OBJECTIVE: To study the serum MMP-3 and OPN levels and the correlations of MMP-3 and OPN with bone metabolic markers and osteoprotegrin and its ligand in aged postmenopausal Chinese women.
METHODS: A total of 120 postmenopausal Chinese female volunteers were divided into three groups: normal bone mineral density, low bone mineral density, and osteoporosis. Serum levels of MMP-3, OPN, osteoprotegrin (OPG), osteoprotegrin ligand (OPGL), bone alkaline phosphate (BAP), osteocalcin, bone cross-linked N-telopeptides of typeⅠcollagen (NTx) and bone cross-linked C-telopeptides of typeⅠcollagen (CTx) were determined. The ratio of OPN to MMP-3 was also determined.
RESULTS AND CONCLUSION: Serum levels of OPN and MMP-3 were significantly higher in the osteoporosis group than in the normal bone mineral density group (P < 0.05). Serum levels of MMP-3 and OPN and OPN/MMP-3 were significantly negatively correlated with OPGL, BAP, and osteocalcin levels, but they were significantly positively correlated with OPG and the ratio of NTx to CTx (P < 0.05) in postmenopausal women. In the osteoporosis group, MMP-3, OPN, and the ratio of OPN to MMP-3 were significantly negatively correlated with OPGL, BAP and osteocalcin levels (P < 0.05), and they were significantly positively correlated with OPG and the ratio of NTx to CTx (P < 0.05). These findings suggest that the increases in serum level of OPN and ratio of OPN to MMP-3 appear possibly as a concomitant event in high bone turnover state, such as postmenopausal osteoporosis.

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