Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7779-7782.doi: 10.3969/j.issn.1673-8225.2011.41.045

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Effectiveness of epidermal growth factor for treating deep second-degree burns in China: A Meta analysis

Zhang Xian-fa, Liang Zi-qian, Zong Shou-kai, Zhao Xue-kai   

  1. Department of Burns and Plastic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-04-11 Revised:2011-05-28 Online:2011-10-08 Published:2011-10-08
  • Contact: Liang Zi-qian, Professor, Master's supervisor, Department of Burns and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China Liangzqian@yahoo.com.cn
  • About author:Zhang Xian-fa★, Studying for master's degree, Department of Burns and Plastic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China zxianfa2003@qq.com
  • Supported by:

    Graduate Education Innovation Fund of Guangxi Zhuang Autonomous Region, No.2010105981002M187*

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Abstract:

BACKGROUND: Epidermal growth factor (EGF) is widely used in the treatment of burn wound, and many articles have confirmed the effectiveness of EGF treatment. However, the deficient number of cases impacts the credibility of the articles.
OBJECTIVE: To assess the effectiveness of EGF for treating deep second-degree burns in China.
METHODS: We searched CMB (1979 to 2010), Wanfang Data (1982 to 2011), VIP (1989 to 2010) and CNKI (1979 to 2010). All searches were updated on January 15, 2007. Randomized controlled trials (RCTs) of EGF for deep second-degree burns were collected. The methodological quality of the included studies was evaluated, and data analyses were performed using the Cochrane Collaboration’s software RevMan 5.0.
RESUITS AND CONCLUSION: A total of 10 RCTs involving 536 deep second-degree burns patients were included. A descriptive analysis of the results was presented: The wound healing time in the EGF treatment group was less than the control group (P < 0.000 01). The wound healing rate between EGF treatment and control groups were significantly different by the second and third weeks, the results were (P=0.000 2, P=0.01). Compared with the control group, the scar proliferation index was significantly lower (P < 0.000 01). But in relieving the pain, there was no statistical difference between the two groups (P=0.16). Results showed that according to the domestic evidence, treatment for second-degree burns with EGF can improve the wound healing rate and lower the scar proliferation index. However, the effectiveness for relieving pains is not obvious.

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