Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7775-7778.doi: 10.3969/j.issn.1673-8225.2011.41.044

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Relationship between muscular atrophy and peroxisome proliferator-activated receptor γ coactivator 1 alpha

Yang Shu, Wen Ye   

  1. Zhanjiang Diving Sport School of Chinese General Administration of Sport, Zhanjiang 524005, Guangdong Province, China
  • Received:2011-06-09 Revised:2011-09-19 Online:2011-10-08 Published:2011-10-08
  • Contact: Wen Ye, Associate researcher, Zhanjiang Diving Sport School of Chinese General Administration of Sport, Zhanjiang 524005, Guangdong Province, China wenyebox@hotmail.com
  • About author:Yang Shu, Associate researcher, Zhanjiang Diving Sport School of Chinese General Administration of Sport, Zhanjiang 524005, Guangdong Province, China zhangjiangys_2008@126.com

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Abstract:

BACKGROUND: Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α) can regulate numerous skeletal muscle functions including mitochondrial biogenesis, substrate oxidation, and muscle fibre type. Recently, PGC-1α has been found to prevent against muscular atrophy.
OBJECTIVE: To summarize and discuss the relationship between PGC-1α and muscular atrophy.
METHODS: A computer-based online retrieval of CNKI and Medline databases was performed by the first author to search  papers published between 2000 and 2010 using the key words “muscle atrophy, PGC-1α, exercise” in Chinese or English. A total of 56 papers were retrieved. According to inclusion and exclusion criteria, 22 papers were included in the final analysis. These papers were summarized from PGC-1α and muscular atrophy, and exercise and PGC-1α.
RESULTS AND CONCLUSION: Enhanced PGC-1α expression can enhance mitochondrial function and human sport ability, reduce oxidative stress and inhibit the expression of muscular atrophy specific gene. Therefore, exercise may inhibit muscular atrophy by regulating PGC-1α expression.

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