Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (41): 7767-7770.doi: 10.3969/j.issn.1673-8225.2011.41.042

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Tissue engineering of post-burn denatured dermal matrix and clinical salvage 

Wang Xiao-chuan, Jiang Du-yin   

  1. Institute of Tissue Engineering of Shandong University, Department of Burn and Plastic Surgery, Second Hospital, Shandong University, Jinan   250033, Shandong Province, China
  • Received:2011-04-08 Revised:2011-05-08 Online:2011-10-08 Published:2011-10-08
  • Contact: Jiang Du-yin, Doctor, Chief physician, Professor, Master’s supervisor, Institute of Tissue Engineering of Shandong University, Department of Burn and Plastic Surgery, Second Hospital, Shandong University, Jinan 250033, Shandong Province, China jdybs2@vip.163.com
  • About author:Wang Xiao-chuan★, Studying for master’s degree, Institute of Tissue Engineering of Shandong University, Department of Burn and Plastic Surgery, Second Hospital, Shandong University, Jinan 250033, Shandong Province, China xiaochuanbest@ 163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81071560*, 30670571*, 30772258*; High-Tech Research and Development Program of Shandong Province, No. 2009GG10002078*; the National Key Basic Research and Development Project, No. 2005CB522603*

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Abstract:

BACKGROUND: The dermal substitute used in composite grafting for deep burn patients can reduce the injury of donor site and improve the utilization of autologous skin and the effect of transplantation. But the treatment costs high and biological activity is limited. It is a pity that the denatured dermis which was discarded after escharectomy can not be recycled.
OBJECTIVE: Through the basic research and clinical application of denatured dermis (matrix), we studied the feasibility of denatured dermal matrix (DDM) reconstruction by tissue engineering and clinical salvage.
METHODS: A computer-based online search was performed for documents on CNKI, PubMed and Medline database from 1970 to 2011. Repetitive papers were excluded.
RESULTS AND CONCLUSION: The satisfactory effect was obtained for recovery of deep burn with the preservation of denatured dermis in the clinic; these results indicate that DDM is not an obstacle to the clinical recycling. The related basic researches show that dermis extracellular matrix contains functional matricryptic peptides and DDM (degradation) is the good substrate of cell protein kinase, which possesses cell chemotactic activity. If the denatured dermal matrix reconstituted in vitro is used successfully, it will help relieve the lack of autologous skin greatly, improve the effect of composite skin transplantation and reduce medical costs.

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