Abstract:

BACKGROUND: It is reported in lots of literature that integrated traditional Chinese medicine and western medicine therapy has better effect on lumbar intervertebral disc protrusion, however, the etiology and pathogenesis of the disease remains elusive.
OBJECTIVE: Although some domestic and foreign scholars have carried out preliminary researches on the proteomics features of syndrome types in traditional Chinese medicine (TCM), the proteomics of syndrome type of lumbar intervertebral disc has not been reported so far.
METHODS: A literature search was performed in Wanfang data, Tshinghua and Medline databases for the relevant research articles published from January 2001 to November 2010 using “syndrome type, traditional Chinese medicine (TCM), protcomics, lumbar intervertebral disk protrusion” in Chinese and English. Inclusion criteria: (1) papers on serum protcomics of lumbar intervertebral disc protrusion. (2) Papers on association of proteomics, the syndrome types and TCM. Exclusive criteria: papers with repetitive contents and meta analysis.
RESULTS AND CONCLUSION: 27 research articles that met the inclusive criteria were selected out of 361 research articles (79 in Chinese, 282 in English) by excluding the irrelevant papers according to their titles and abstracts. We conclude that the TCM syndrome types of some diseases relate to serum proteomics and the expression of some specific marker proteins may be associated with disc degeneration. Although the association between lumbar intervertebral disk protrusion and some syndrome types (blood stasis syndrome, damp-heat syndrome and cold-damp syndrome) has been validated by some experiments and clinical practice, there is still a lack of research on the relationship between proteomics and lumbar intervertebral disk protrusion.